NMR and structural studies of gold(I) chloride adducts with bidentate 2-, 3- and 4-pyridyl phosphines

Anti-cancer potential of gold complexes

“…Research has continued in this area with the aim of targeting mitochondrial DNA although toxic side-effects precluded clinical development of (6) (McKeage et al, 2002). The cationic compounds related to (6) can be chemically modified to moderate their lipophilicity by substituting the phosphorus-bound phenyl groups with, for example, pyridyl groups (Berners-Price et al, 1999). Alternatively, the nature of the bridge between phosphorus atoms can be changed but these water-soluble derivatives are inactive (Berners-Price et al, 2005).…”

Targeting the mitochondrial cell death pathway with gold compounds

“…The position of the N-atom in the pyridyl ring influences the interaction with solvent providing a series of compounds which are structurally similar to [Au(dppe) 2 ] + , and in which the hydrophilic character covers a very large range. The 3-and 4-pyridyl complexes (4 and 5, Scheme 2), exist as simple monomeric cations in the solid state and in solution and have a much higher water solubility than the 2-pyridyl complex (6) which crystallises in the solid state as a dimer [76,78].…”

Coordination complexes of silver(I) with tertiary phosphine and related ligands

“…Silver(I) complexes of bidentate pyridylphosphines are of particular interest to us in their context as potential antitumour agents [9,10]. Not included in this review is any description of silver(I) salts with the various organoborates (e.g.…”