NLR and CRP to albumin ratio as a predictor of in-hospital mortality in the geriatric ED patients

Ayrancı, Mustafa Kürşat; Küçükceran, Kadir; Dündar, Zerrin Defne

doi:10.1016/j.ajem.2021.01.053

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…4,9,11,12 Two previous studies reported NLRs for predicting inhospital mortality among elderly patients of 7.1 and 7.7, respectively. 13,14 NLR was significantly higher in patients who died than in those who survived in this study (P < 0.001). NLR of !4.02 was associated with increased mortality.…”

Section: Discussionmentioning

confidence: 47%

Relationships of the neutrophil–lymphocyte and CRP–albumin ratios with the duration of hospitalization and fatality in geriatric patients with COVID-19

et al. 2021

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Objective The aim of this study was to determine the associations of the neutrophil–lymphocyte ratio (NLR) and C-reactive protein (CRP)–albumin ratio (CAR) with the duration of hospital stay and fatality rate in geriatric patients with coronavirus disease 2019 (COVID-19). Methods Patients older than 65 years with polymerase chain reaction-positive COVID-19 were included. Neutrophil, lymphocyte, CRP, albumin, and demographic data and the duration of hospitalization were recorded. Results The mean length of stay was 15 days. NLR and CAR were significantly higher in patients who died than in those who survived. The cutoffs predictive of mortality were 4.02 (area under the curve [AUC] = 0.717) for NLR and 23 for CAR (AUC = 0.781). The fatality rate among patients who required inpatient treatment was 33%. Conclusion NLR and CAR, which can be calculated inexpensively and quickly at the first admission to the hospital, are extremely useful for estimating the duration of hospitalization and risk of mortality in geriatric patients with COVID-19. Using these data, treatment can quickly be intensified when needed.

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Section: Discussionmentioning

confidence: 47%

Relationships of the neutrophil–lymphocyte and CRP–albumin ratios with the duration of hospitalization and fatality in geriatric patients with COVID-19

et al. 2021

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“…Albumin, as an important evaluation indicator of systemic nutritional status, is considered to be one of a series of systemic reactions caused by systemic inflammation. It has also been reported that the decrease in albumin is followed by the increase in CRP (Ayranci et al, 2021;Con et al, 2021). Such a simple and practical index can also be used as an important evaluation index for patients' condition judgment and treatment choices.…”

Section: Discussionmentioning

confidence: 95%

Effects of probiotics on gastric cancer‐related inflammation: A systematic review and meta‐analysis

Yang

Meng

Wang

et al. 2022

Journal of Food Biochemistry

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Gastric cancer is the fifth most common type of malignant tumor in the world and the third leading cause of death in cancer patients . At present, surgical treatment is still one of the main measures to treat gastric cancer. However, gastric cancer patients often have malnutrition due to increased catabolism, weakened anabolism, and decreased immune function, which increases the incidence of postoperative complications and mortality (Lin et al., 2021). As long as the gastrointestinal function is normal, enteral nutrition support should be the first choice . Enteral nutrition support helps to improve the nutritional status of postoperative patients, promote early recovery of intestinal function, enhance immunity, and reduce the incidence of postoperative complications (Wan et al., 2021). Probiotics refer to bacteria that are beneficial to the human body. Probiotics (various

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“…Similar observations have been made in situations other than infectious catabolic and inflammatory states, such as hospitalized older people [ 51 ], cancer patients [ 52 ], and the postoperative period [ 53 ]. As in the present study, previous studies have considered the potential capacity of the CRP/SA ratio to have greater predictive capacity than each of the components of the ratio alone in COVID-19 [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. Although with a very high heterogeneity, in general, the existing literature demonstrates the prognostic capacity of CRP/SA ratio in the hospitalized COVID-19 patient, as well as that this predictive capacity is higher than that of each one of the parameters alone [ 36 ].…”

Section: Discussionmentioning

confidence: 95%

“…The main limitation of these studies was the usual small sample size, as shown in recent meta-analysis, that confirmed the utility of SA as a prognostic marker in hospitalized acute COVID-19, although again indicating a very high heterogeneity of the analyzed literature, as well as small samples [ 26 , 27 ]. Elsewhere, authors have tried to improve the prognostic capacity of SA by analyzing ratios including other analytical parameters alone [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. As a whole, these studies indicate an increased prognostic value than SA alone; however, samples have generally been small, thus limiting the strength of the findings reported in studies [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19

et al. 2022

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(1) Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551–0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001–1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865–0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188–1.819; p < 0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course.

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NLR and CRP to albumin ratio as a predictor of in-hospital mortality in the geriatric ED patients

Cited by 28 publications

References 27 publications

Relationships of the neutrophil–lymphocyte and CRP–albumin ratios with the duration of hospitalization and fatality in geriatric patients with COVID-19

Relationships of the neutrophil–lymphocyte and CRP–albumin ratios with the duration of hospitalization and fatality in geriatric patients with COVID-19

Effects of probiotics on gastric cancer‐related inflammation: A systematic review and meta‐analysis

C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19

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