2018
DOI: 10.18632/aging.101359
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Abstract: The long non-coding RNA (lncRNA) NKILA (nuclear transcription factor NF-κB interacting lncRNA) functions as a suppressor in human breast cancer and tongue cancer. However, the clinical significance and biological roles of NKILA in esophageal squamous cell carcinoma (ESCC) remain unknown. In this study, we showed that NKILA was downregulated in ESCC tissues and cancer cells compared with their normal counterparts. Low NKILA expression correlated with large tumor size and advanced TNM stage, and predicted poor o… Show more

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Cited by 38 publications
(48 citation statements)
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References 37 publications
(48 reference statements)
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“…Our data showed that inference of NKILA did not significantly alter either TAK1 phosphorylation or miR‐182 levels. In addition, it has been reported that NKILA promotes the metastasis of esophageal squamous cell carcinoma via MMP9 and MMP14 . Consistent with our data, MMP9 and MMP14 are regulated by NF‐κB and play a significant role in EMT .…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Our data showed that inference of NKILA did not significantly alter either TAK1 phosphorylation or miR‐182 levels. In addition, it has been reported that NKILA promotes the metastasis of esophageal squamous cell carcinoma via MMP9 and MMP14 . Consistent with our data, MMP9 and MMP14 are regulated by NF‐κB and play a significant role in EMT .…”
Section: Discussionsupporting
confidence: 92%
“…In addition, it has been reported that NKILA promotes the metastasis of esophageal squamous cell carcinoma via MMP9 48 and MMP14. 49 Consistent with our data, MMP9 and MMP14 are regulated by NF-jB [50][51][52] and play a significant role in EMT. 53 Together, these data indicate that NKILA mediates TGF-binduced EMT by negatively regulating several NF-jB target genes.…”
Section: Discussionsupporting
confidence: 91%
“…15,16 Moreover, Yang et al 18 demonstrated that knockdown of NKILA expression promoted cell viability and migration, and reversed cell apoptosis F I G U R E 4 The molecular mechanism of NKILA in rectal cancer cell. We found NKILA overexpression dramatically repressed rectal cancer cell proliferation, migration, and invasion.…”
Section: Discussionmentioning
confidence: 99%
“…15,16 Moreover, Yang et al 18 demonstrated that knockdown of NKILA expression promoted cell viability and migration, and reversed cell apoptosis F I G U R E 4 The molecular mechanism of NKILA in rectal cancer cell. [14][15][16][17][18][19][20] In addition, NKILA was found to enhance the the anticancer effects of baicalein in hepatocellular carcinoma through modulating NF-κB signaling. B, NKILA overexpression inhibits p65 nuclear translocation and induces p65 cytoplasmic retention and the cytotoxicity of X-ray radiation.…”
Section: Discussionmentioning
confidence: 99%
“…Long non‐coding RNAs, a subset of non‐coding transcripts with more than 200 nucleotides in length, have been shown to play important roles in numerous biological processes, for example inflammation, immunity and various cancers . With the development of high throughput RNA sequencing approach, a variety of novel lncRNAs were identified.…”
Section: Introductionmentioning
confidence: 99%