Nitrous Oxide for Colonoscopy

Fixed 50:50 mixture of nitrous oxide and oxygen to reduce lumbar‐puncture‐induced pain: a randomized controlled trial

“…Our study is the first adequately powered, randomized, double‐blind trial to compare fixed 50% N 2 O−O 2 mixture versus placebo, given during an LP. Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes .…”

“…Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes . A recent meta‐analysis found that nitrous oxide was as efficient as and safer than various pain relief methods used during colonoscopy .…”

Fixed 50:50 mixture of nitrous oxide and oxygen to reduce lumbar‐puncture‐induced pain: a randomized controlled trial

“…Our study is the first adequately powered, randomized, double‐blind trial to compare fixed 50% N 2 O−O 2 mixture versus placebo, given during an LP. Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes .…”

“…Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes . A recent meta‐analysis found that nitrous oxide was as efficient as and safer than various pain relief methods used during colonoscopy .…”

The Use of a Fixed 50:50 Mixture of Nitrous Oxide and Oxygen to Reduce Lumbar Puncture-Induced Pain in the Emergency Department: A Randomized Controlled Trial

“…Anxiety and pain before an LP are possibly more frequent in an emergency setting, and such parameters could have had a negative impact on the analgesic effect of the nitrous oxide [22]. Indeed, previous studies focusing on procedural pain [23][24][25][26][27] have consistently shown a positive effect, but these were not performed on adults in an emergency setting. Two studies performed on adults for moderate traumatic acute pain treatment in the ED were also positive [28,29].…”

Use of diphenhydramine as an adjunctive sedative for colonoscopy in patients on chronic opioid therapy: a randomized controlled trial

“…11,12 Based on anecdotal data, the use of adjunct sedatives or deep sedation is often used with these patients. [19][20][21][22][23] Because of its hypnotic and sedative properties, diphenhydramine is recommended for endoscopic procedures in difficult-to-sedate patients, but the studies supporting its use have yielded conflicting results. 13,18 We designed a randomized controlled study to systemically analyze the use of diphenhydramine as an adjunct to routinely used sedatives in patients on chronic opioids.…”

Fixed 50:50 mixture of nitrous oxide and oxygen to reduce lumbar‐puncture‐induced pain: a randomized controlled trial

“…Our study is the first adequately powered, randomized, double‐blind trial to compare fixed 50% N 2 O−O 2 mixture versus placebo, given during an LP. Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes .…”

“…Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes . A recent meta‐analysis found that nitrous oxide was as efficient as and safer than various pain relief methods used during colonoscopy .…”

The Use of a Fixed 50:50 Mixture of Nitrous Oxide and Oxygen to Reduce Lumbar Puncture-Induced Pain in the Emergency Department: A Randomized Controlled Trial

“…Anxiety and pain before an LP are possibly more frequent in an emergency setting, and such parameters could have had a negative impact on the analgesic effect of the nitrous oxide [22]. Indeed, previous studies focusing on procedural pain [23][24][25][26][27] have consistently shown a positive effect, but these were not performed on adults in an emergency setting. Two studies performed on adults for moderate traumatic acute pain treatment in the ED were also positive [28,29].…”

Use of diphenhydramine as an adjunctive sedative for colonoscopy in patients on chronic opioid therapy: a randomized controlled trial

“…11,12 Based on anecdotal data, the use of adjunct sedatives or deep sedation is often used with these patients. [19][20][21][22][23] Because of its hypnotic and sedative properties, diphenhydramine is recommended for endoscopic procedures in difficult-to-sedate patients, but the studies supporting its use have yielded conflicting results. 13,18 We designed a randomized controlled study to systemically analyze the use of diphenhydramine as an adjunct to routinely used sedatives in patients on chronic opioids.…”

Fixed 50:50 mixture of nitrous oxide and oxygen to reduce lumbar‐puncture‐induced pain: a randomized controlled trial

“…Our study is the first adequately powered, randomized, double‐blind trial to compare fixed 50% N 2 O−O 2 mixture versus placebo, given during an LP. Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes .…”

“…Our result showing both good efficacy and safety is in accordance with previous studies focusing on other procedural pain . Indeed, nitrous oxide is used only rarely in adults, for minor painful procedures, and this use is based on a very limited number of well conducted trials with appropriate control groups and sample sizes . A recent meta‐analysis found that nitrous oxide was as efficient as and safer than various pain relief methods used during colonoscopy .…”

The Use of a Fixed 50:50 Mixture of Nitrous Oxide and Oxygen to Reduce Lumbar Puncture-Induced Pain in the Emergency Department: A Randomized Controlled Trial

“…Anxiety and pain before an LP are possibly more frequent in an emergency setting, and such parameters could have had a negative impact on the analgesic effect of the nitrous oxide [22]. Indeed, previous studies focusing on procedural pain [23][24][25][26][27] have consistently shown a positive effect, but these were not performed on adults in an emergency setting. Two studies performed on adults for moderate traumatic acute pain treatment in the ED were also positive [28,29].…”

Use of diphenhydramine as an adjunctive sedative for colonoscopy in patients on chronic opioid therapy: a randomized controlled trial

“…11,12 Based on anecdotal data, the use of adjunct sedatives or deep sedation is often used with these patients. [19][20][21][22][23] Because of its hypnotic and sedative properties, diphenhydramine is recommended for endoscopic procedures in difficult-to-sedate patients, but the studies supporting its use have yielded conflicting results. 13,18 We designed a randomized controlled study to systemically analyze the use of diphenhydramine as an adjunct to routinely used sedatives in patients on chronic opioids.…”