Nitrogen Balance Responses of Young Men to Lysine Supplementation of Bread

Rice, H. L.; Shuman, A. C.; Matthias, R.; Flodin, Nestor W.

doi:10.1093/jn/100.7.847

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…Improvement in nitrogen retention of wheat protein with lysine supplementation has been repeatedly confirmed in experimental animals [10]. It has also been confirmed by child growth studies [11][12][13][14] and nitrogen balance studies in infants [15][16][17], children [18][19][20], and adults [21][22][23][24][25]. All of these studies have been performed with "captive" populations (in hospitals, orphanages, schools, and universities).…”

Section: Introductionmentioning

confidence: 82%

Lysine Fortification of Wheat Flour Improves Selected Indices of the Nutritional Status of Predominantly Cereal-Eating Families in Pakistan

et al. 2004

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Wheat provides more than 50% of the protein and calorie intake of the population of Pakistan. Legumes and animal protein that could complement the amino acid pattern of wheat, in which lysine is the first limiting amino acid for utilization of protein, are not affordable by members of lower socioeconomic groups in developing countries. The purpose of the study was to determine whether lysine fortification of wheat flour would have a positive impact on populations consuming a predominantly wheat-based diet. A double-blind study was carried out for three months on the outskirts of Peshawar, Pakistan. Forty families received wheat flour fortified with lysine, and 40 families received wheat flour without lysine. Wheat provided 59% of the protein for men, 65% for women, and 58% for children. The weight and height of the children in both groups increased during the study, but the increase was significantly greater in the lysine group. Hemoglobin increased significantly in the women receiving lysine-fortified flour. Transferrin levels increased significantly in men, women, and children in the lysine group as compared with those in the control group. Prealbumin increased significantly in adults receiving additional lysine but decreased in children. Men, women, and children in the lysine-supplemented families had significant increases in CD4, CD8, and complement C3 as compared with controls. These results indicate that lysine fortification of wheat flour can significantly improve sensitive indicators of nutritional status in a population consuming a diet in which 58% to 65% of the protein, depending on age and sex, is supplied by wheat.

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Section: Introductionmentioning

confidence: 82%

Lysine Fortification of Wheat Flour Improves Selected Indices of the Nutritional Status of Predominantly Cereal-Eating Families in Pakistan

et al. 2004

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“…When wheat protein is fortified with lysine, improvement in nitrogen retention has been repeatedly observed in experimental animals [5], young children [6,7], and adults [8,9]. In 1996-97, a field study was conducted in a predominantly wheat-eating community outside Peshawar, Pakistan [10].…”

Section: Introductionmentioning

confidence: 99%

Lysine-Fortified Wheat Flour Improves the Nutritional and Immunological Status of Wheat-Eating Families in Northern China

et al. 2004

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The purpose of this study was to determine the impact of the fortification of wheat flour with lysine on selected health indicators among farm families obtaining 58% to 67% of their dietary protein from wheat. A man, a woman, and a child aged 5 to 12 years were studied from each of 88 families in a village near Huixian City, Henan Province, China. Half of the families received wheat flour fortified with 3 g of lysine per kilogram for three months, and the other half received wheat flour without fortification. The results showed a significantly greater gain in the height and weight of children receiving lysine-fortified wheat flour. Hemoglobin values were not affected. The mean prealbumin values of adult men and women were higher in those receiving lysine. The numbers of CD3 T cells increased significantly in women and children, as did the complement fraction C3 and IgG in men, IgA in women, and IgG, IgA, IgM, and C3 in children. These results indicate that lysine fortification of wheat flour can significantly improve some indicators of the nutritional status and immune function of family members consuming a wheat-based diet.

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“…Many studies relating to effect of lysine supplementation on nitrogen balance improvement Department of Foods and Nutrition, Punjab Agricultural University, Ludhiana 141004, India. have been reported in the literature (Rice et al, 1970;Clark et al, 1962;Jones et al, 1956). However, absorption of lysine from different dietary regimes has not been well studied.…”

mentioning

confidence: 89%

Lysine absorption from chickpea (Cicer arietinum) and milk-supplemented wheat diets at two levels of energy

Hundal¹,

Hira²

1988

J. Agric. Food Chem.

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Nitrogen Balance Responses of Young Men to Lysine Supplementation of Bread

Cited by 12 publications

References 19 publications

Lysine Fortification of Wheat Flour Improves Selected Indices of the Nutritional Status of Predominantly Cereal-Eating Families in Pakistan

Lysine Fortification of Wheat Flour Improves Selected Indices of the Nutritional Status of Predominantly Cereal-Eating Families in Pakistan

Lysine-Fortified Wheat Flour Improves the Nutritional and Immunological Status of Wheat-Eating Families in Northern China

Lysine absorption from chickpea (Cicer arietinum) and milk-supplemented wheat diets at two levels of energy

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