Nitride-Based Microarray Biochips: A New Route of Plasmonic Imaging

Abstract

The desire to improve human lives has led to striking development in biosensing technologies. While the ongoing research efforts are mostly dedicated to enhancing speed and sensitivity of the sensor, a third consideration that has become increasingly important is compactness, which is strongly desired in emergency situations and personal health management. Surface plasmon resonance imaging (SPRi) is one of the few techniques that can potentially fulfill all the three goals, considering its multiplexed assay capability. However, miniaturizing SPRi biosensors remains elusive as it entails complicated optical gears. Here, we significantly slim the architecture of SPRi devices by visualizing the varied local density of states around analytes. The unusual detection scheme is realized by building a gain-assisted SPRi with InGaN quantum wells (QWs), where the QW−plasmon coupling efficiency hinges on localized refractive index variation. This new modality abolishes the prism, the polarizer, and the beam-tracking components in the most used Kretschmann configuration without compromising the performances.

Surface Plasmon Resonances in Sierpinski-Like Photonic Crystal Fibers: Polarization Filters and Sensing Applications

“…Surface plasmon resonances (SPRs) are enhanced electromagnetic fields bound to metal/dielectric interfaces through resonantly coupled optical and electronic excitations [ 1 ]. Due to their myriad applications in sub-diffraction nanophotonic devices for imaging, communications, energy harvesting, and sensing/biosensing applications, SPRs are gaining considerable attention during the last years [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. In particular, SPRs allow for real-time and label-free monitoring of molecular-binding events (near the interface) through detection of small changes in the local refractive index [ 12 , 13 , 14 , 15 ].…”

Real Time Microwave Biochemical Sensor Based on Circular SIW Approach for Aqueous Dielectric Detection

“…The structure become more complex as the optimization been made. Nowadays, there are extensive research studies on SPR technique in material characterization especially for biosensing application that explore and improving this technique 13–16 . This approach become more advanced and the innovation on magneto plasmonic structure make the sensing capability become faster and accurate.…”

“…Apart from that, recent SPR development has discovered an improvement biosensing technology called SPR imaging which physically compact, reusable, inherent polarized emission and extremely high detection sensitivity. These features brings the SPR technique to the next future generation of characterization instrument 16 . Nevertheless, instead of optical technique, this manuscript focusing on microwave characterization approach as it can be integrate in sensor electronic system based on PCB integrated design such as MEMS sensor.…”

Towards rational design and optimization of near-field enhancement and spectral tunability of hybrid core-shell plasmonic nanoprobes

“…Considerable effort has been directed towards the design of more sensitive and efficient metal nanoparticles for biosensing 1–3 and imaging 4 . For instance, several novel detection schemes based on magneto-plasmonics 5,6 and metallic thin films 7,8 have been demonstrated. Of particular interest in the sensing domain and relevant to our current study is the capability of these metal structures in enhancing the electromagnetic field in its vicinity, which can sense minute perturbations in the surrounding and also amplify the weak Raman signal arising from a biological sample or dilute analytes (surface enhanced Raman scattering (SERS)) 9 .…”