1993
DOI: 10.1152/ajplung.1993.265.2.l110
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Abstract: The close proximity of pleural mesothelial cells (PMC) and mononuclear cells during pleural inflammation suggests that leukocyte-derived products (e.g., cytokines) may play an important role in modulating PMC function. The purpose of this study was to determine whether certain cytokines and bacterial products induce PMC to produce nitric oxide (NO). Confluent monolayers of rat PMC were exposed to tumor necrosis factor (TNF), interleukin-1 beta (IL-1), gamma-interferon (IFN), or lipopolysaccharide (LPS) individ… Show more

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Cited by 26 publications
(37 citation statements)
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“…The inducible form of nitric oxide synthase is capable of producing micromolar quantities of nitric oxide radicals over a prolonged period of time. Pleural mesothelial cells produce large quantities of nitric oxide radicals in response to the stimulation by cytokines, lipopolysaccharide (LPS), and particulates [6, 7]. Inducible nitric oxide synthase may thus contribute to the control of infections in the pleural space and may be involved in pleural inflammation from other insults.…”
Section: Defense Mechanisms Of the Pleuramentioning
confidence: 99%
“…The inducible form of nitric oxide synthase is capable of producing micromolar quantities of nitric oxide radicals over a prolonged period of time. Pleural mesothelial cells produce large quantities of nitric oxide radicals in response to the stimulation by cytokines, lipopolysaccharide (LPS), and particulates [6, 7]. Inducible nitric oxide synthase may thus contribute to the control of infections in the pleural space and may be involved in pleural inflammation from other insults.…”
Section: Defense Mechanisms Of the Pleuramentioning
confidence: 99%
“…For instance, recent studies suggest that mesothelial cells may produce collagen [21] and nitric oxide (NO) when exposed to cytokines and bacterial products [27]. Confluent layers of rat mesothelial cells generated large amounts of NO when exposed to IL-1β, TNF-α and lipopolysaccharide, while interferon-γ (IFN-γ) was less effective [28]. Furthermore, mesothelial cells exposed to asbestos fibres produced antioxidant enzymes [29] and showed an increased expression of adhesion molecules on their surface.…”
Section: Mesothelial Cellsmentioning
confidence: 99%
“…The plasticity demonstrated by the frog pericardial mesothelium following ANG II stimulation highlights the putatively important role of the PP in the hormonal-dependent regulation of both the PF and the MIF. Future investigations, including immunolabeling and permeability studies, will be necessary to clarify whether and to what extent the frog PP is a paracrine-autocrine source, and at the same time a target of peptidic hormones (Kuwara et al, 1992), cytokines, nitric oxide (Owens and Grisham, 1993), and growth factors (Gerwin et al, 1987;Corda et al, 1997), as suggested in mammals.…”
Section: Discussionmentioning
confidence: 99%