Nitric oxide synthase inhibitors protect cholinergic neurons against AlCl3 excitotoxicity in the rat brain

Stevanović, Ivana; Jovanović, Marina; Čolić, Miodrag; Jelenković, A; Bokonjić, Dubravko; Ninković, Milica

doi:10.1016/j.brainresbull.2010.01.004

Cited by 27 publications

(9 citation statements)

References 34 publications

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“…3). Studies have shown that inhibition of nitric oxide synthase protect cholinergic neurons against AlCl 3 excitotoxicity in the rat brain 45 . Studies have also shown the activation of stress response results primarily in the increased Herbal drink consisting of all the ingredients as that of BHD except bacosides failed to show significant in most of the AlCl 3 induced impairments.…”

Section: Resultsmentioning

confidence: 99%

Brahmi herbal drink mitigates aluminium chloride induced cognitive impairments

et al. 2017

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Aluminium chloride (AlCl 3 ) is neurotoxic and has been proposed to be one of the environmental factors responsible for neurodegenerative disease like Alzheimer's and Parkinson's disorders. It also causes learning and memory deficit. Bacopa monniera is well known for its memory enhancing property in traditional Indian system of medicine. Cognitive-enhancing and neuromodulatory property of brahmi herbal drink (BHD), a nutraceutical product from Bacopa monniera extract. BHD was evaluated for physicochemical, sensory attributes and stability studies. Overall acceptability of BHD was good according to hedonic scale/ratings. Stability of the drink is for 6 months without losing its activity. Further, cognitive enhancing and neuromodulatory propensity of BHD was evaluated against AlCl 3 treatment in rats. Administration of AlCl3 (100 mg/kg) daily for 23 days significantly increased cognitive impairment as evaluated in elevated plus maze (EPM) and Morris water maze (MWM) tests. BHD supplementation improved cognitive ability by decreasing the transfer and escape latency of EPM and MWM tests respectively. Results further elucidate that BHD supplementation decreased acetylcholine esterase activity and nitric oxide levels by down-regulating AChE and iNOS expression respectively. BHD supplementation showed it neuroprotective efficacy by up-regulating BDNF expression. AlCl3 induced lipid peroxidation and reactive oxygen species generation was significantly alleviated by BHD and restored antioxidant status levels. All these results demonstrated the cognitive-enhancing and neuromodulatory potential of BHD in counteracting the damage inflicted by AlCl 3 on rat brain.

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Section: Resultsmentioning

confidence: 99%

Brahmi herbal drink mitigates aluminium chloride induced cognitive impairments

et al. 2017

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“…It has been shown that AG injection reversed hypoxia-induced retrograde memory destruction (17). Moreover, the drug might protect aluminum chloride-provoked memory defect (18). In contrast, the enhancing outcome of the effect of atorvastatin on short-term spatial memory recognition has been reversed by AG administration (19).…”

Section: Discussionmentioning

confidence: 99%

“…Protective effects of AG have been shown in peripheral nerves' functional and structural defi cits induced by DM (11) and transient focal cerebral ischemia (12) and stroke (13). Paradoxical results are available relating to the effect of AG on memory of animals including positive (14)(15)(16)(17)(18) and negative effects (19)(20)(21)(22). To our knowledge, few studies have been published concerning the effect of ip administration of AG on memory and anti/apoptotic genes in diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats

Alipour¹,

Amini²,

Adineh³

et al. 2016

BLL

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Memory impairment is a common disorder in diabetes mellitus which is associated with hippocampal neuronal apoptosis. The present study was conducted to examine the effect of one-week intraperitoneal (ip), administration of aminoguanidine (AG) on passive avoidance learning (PAL) and Bcl-2 family gene expression in the hippocampus of rats. Sixty male rats were divided into ten groups: non-diabetic/diabetic animals with/without AG (50, 100, 200 and 400 mg/kg, ip) treatment for one week. PAL and Bcl-2 family genes were examined. AG (100 and 200 mg/kg) improved both memory and Bax, Bak, Bcl-2 and Bcl-xl defi ciency signifi cantly in diabetic rats. AG treatment also ameliorated the diabetes-induced changes in (Bcl-2+Bcl-xl)/(Bak+Bax) ratios considerably. These results propose that one-week ip administration of AG may recover the defi cit cognition in diabetic rats via enhancing (Bcl-2+Bcl-xl)/(Bak+Bax) proportions (Tab. 2, Fig. 4, Ref. 55). Text in PDF www.elis.sk.

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“…The influence of iNOS seems to have an essential position in the mechanism of mitochondrial damage, which was demonstrated by CO activity reduction. In our previous studies, we found iNOS positive cells in hippocampus 30 days after both saline solution and AlCl 3 administration [22]. Also, we previously revealed a greater inflammatory response over immunoreactivity of astrocytes and phagocytic microglia in AlCl 3 -injected animals [23].…”

Section: Discussionmentioning

confidence: 99%