2011
DOI: 10.1016/j.micpath.2011.03.013
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Abstract: The functions of inducible nitric oxide synthase (iNOS) activity in protection against microbial insults are still controversial. In this study, we explored the role of iNOS in protection against Coccidioides infection in mice. We observed that wild-type (WT) and iNOS−/− mice showed similar percent survival and fungal burden in their lungs at days 7 and 11 after intranasal challenge with Coccidioides. Vaccinated WT and iNOS−/− mice revealed comparable fungal burden in their lungs and spleen at 7 and 11 days po… Show more

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Cited by 23 publications
(42 citation statements)
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“…Quantification of leukocyte subpopulations in subcutaneous tissue. Flow cytometry was used to determine the percentages and absolute numbers of CD4 ϩ T cells, CD8 ϩ T cells, B cells, natural killer cells (NK), neutrophils (PMN), macrophages (M⌽), eosinophils (EOS), and dendritic cells (DC) in abscess and dLN-derived leukocytes, as previously described (15,24). All fluorochrome-conjugated antibodies used in this study were purchased from BD Biosciences (Franklin Lakes, NJ).…”
Section: Methodsmentioning
confidence: 99%
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“…Quantification of leukocyte subpopulations in subcutaneous tissue. Flow cytometry was used to determine the percentages and absolute numbers of CD4 ϩ T cells, CD8 ϩ T cells, B cells, natural killer cells (NK), neutrophils (PMN), macrophages (M⌽), eosinophils (EOS), and dendritic cells (DC) in abscess and dLN-derived leukocytes, as previously described (15,24). All fluorochrome-conjugated antibodies used in this study were purchased from BD Biosciences (Franklin Lakes, NJ).…”
Section: Methodsmentioning
confidence: 99%
“…ϩ CD11c ϩ (24). Cell numbers were normalized to the dissected hypodermis tissue weight (measured in grams).…”
Section: And Cd11bmentioning
confidence: 99%
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“…There is some uncertainly about the role of iNOS. A broad-spectrum NOS inhibitor increased the susceptibility of DBA/2 mice to C. immitis [69]. In contrast, a Nos2 mutant mouse strain was not more susceptible [70].…”
Section: Immunologymentioning
confidence: 99%
“…In contrast, a Nos2 mutant mouse strain was not more susceptible [70]. However, that mutation was made in C57BL/6 mice, which themselves make very little NO in response this infection [69]. …”
Section: Immunologymentioning
confidence: 99%