Nitric Oxide Regulates Wound Healing

Schäffer, Michael; Tantry, Udaya S.; Gross, Steven S.; Wasserkrug, Hannah L.; Barbul, Adrian

doi:10.1006/jsre.1996.0254

Cited by 249 publications

(185 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…VEGF, as an important angiogenic factor, and NO, as a vasodilator, play a potent role in the formation of new vessels (angiogenesis) in the wound healing process [8][9][10][11]17]. There is evidence that the expression of VEGF and NO is reduced in patients with diabetes, and this diminution is associated with delayed healing in the wounds [12,[24][25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers

et al. 2014

View full text Add to dashboard Cite

Abstract-This study investigated the effect of low-intensity cathodal direct current on the release of plasma vascular endothelial growth factor (VEGF) and nitric oxide (NO) in diabetic foot ulceration. Twenty type 2 diabetic patients with foot ulceration and thirteen age-matched healthy subjects were enrolled. Patients were randomly assigned to electrical stimulation (ES) (n = 10) or sham ES (placebo, n = 10) groups. The ES group received cathodal direct current (1.48 +/-0.98 mA) for 1 h/d, 3 d/wk for 4 wk (12 sessions). Blood samples were collected for VEGF and NO measurement in the first and last treatment sessions before and after intervention. Wound surface area and skin temperature were measured at the 1st, 6th, and 12th sessions. VEGF significantly increased in the ES group compared with the placebo group after the 1st (106.61 +/-79.50 and 40.88 +/-26.20, respectively) and 12th sessions (109.28 +/-67.30 and 34.79 +/-13.20, respectively). NO level also increased significantly in the ES group compared with the placebo group after the 12th session (44.21 +/-14.00 and 35.25 +/-11.00, respectively). The increase of skin temperature was significantly higher in the ES group than the placebo group. Application of low-intensity ES increases the expression of VEGF and NO, which may lead to improved blood flow and tissue temperature and, consequently, wound healing in diabetic foot ulceration.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Nitric oxide (NO) is another mediator that plays an important role in the wound healing process [17]. NO synthesis occurs during wound healing and regulates important parts of wound healing, such as chemotaxis, angiogenesis, cellular proliferation, and epithelialization [18][19].…”

Section: Introductionmentioning

confidence: 99%

Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers

et al. 2014

View full text Add to dashboard Cite

show abstract

“…13 Gülcan et al and Schaffer et al previously showed that nebivolol had positive effects on wound healing. 14,15 However, according to our knowledge, this study is the first to investigate the effects of nebivolol on fracture healing. Data are presented as mean ± standard deviation (SD); data were tested using the Kruskal-Wallis test and the Dunn's method was used for post hoc testing; p-value < 0.05 was considered statistically significant; p a < 0.05, compared to the control group.…”

Section: Discussionmentioning

confidence: 96%

Effect of nebivolol on fracture healing: An experimental rat model

Metineren¹,

Dülgeroğlu²,

Metineren³

et al. 2017

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Bone metabolism is a complex system, and fracture healing is one of its most important functions. Many circumstances can influence this process. Chronic drug use in elderly populations can affect bone healing, and inadequate tissue perfusion, increased free radicals and adverse drug effects can negatively influence fracture healing. Nebivolol, an anti-hypertensive drug that selectively blocks β1 receptors, effectively reduces blood pressure by inducing peripheral vasodilation. Nebivolol also exerts anti-oxidant effects by stimulating nitric oxide (NO) synthesis. Many studies show that NO protects the vascular endothelium and improves fracture healing.

show abstract

“…Administration of NOS inhibitors results in delayed reepithelization and collagen formation (4). Several studies have implicated that NO might plays a vital role in all the phases of wound healing (8).…”

Section: Discussionmentioning

confidence: 99%

“…Systemic diseases which delay wound healing is another significant point that effects the choice of suture material and represent major clinical importance (2). Diabetic wound healing impairment is one of the most well-known chronic wound situations (4). The factors ensuring appropriate intercellular communication during wound repair are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Effects of Polyglecaprone 25, Silk and Catgut Suture Materials on Oral Mucosa Wound Healing in Diabetic Rats: An Evaluation of Nitric Oxide Dynamics

Yılmaz¹,

İnal²,

Muğlalı³

et al. 2010

Med Oral

View full text Add to dashboard Cite

Objectives: The purpose of this study is to investigate the effects of monocryl (Polyglecaprone 25), silk and catgut suture materials on wound healing in diabetic rats and to evaluate NO (nitric oxide) dynamics. Study desing: Fourty-eight male Wistar-Albino rats weighting 220-270 g were used in this study. The rats were categorized into 2 groups, as control group (n=24) and streptozotocin (STZ) induced diabetic group (n=24). For each group, incision wounds were created on the inner cheeck mucosa of the animals and wounds were closed primarily with three different types of sutures. These materials were sized 3-0 monocryl (polyglecaprone 25), silk and catgut sutures swaged on. Excisional biopsies were performed at 2nd, 7th, 14th and 21st day (2 rats per day) from the initial surgical procedure. Effects of these suture materials on wound healing and NOS (nitric oxide synthase) activities were compared immunohistochemically in the study. eNOS and iNOS (Endothelial and induced nitric oxide synthase) activities were classified as mild (+), moderate (++) and severe (+++). Results: Mild eNOS activities were seen in both diabetic and control groups at 2nd day specimens. Activities of silk and catgut were similar both in diabetic and control groups at 14th day, this activity in monocryl was mild. 21st day specimens revealed that monocryl has mild eNOS activity than silk and catgut sutures. iNOS activities in diabetic group were greater than control groups and the degrees of the activity in monocryl, silk and catgut sutures were mild, severe and moderate at the 7th day. At the 14th day there was no iNOS activity in diabetic monocryl group. Conclusion: All of the materials have the potential capacity to be well tolerated however monocryl seemed to have more benefical effects on wound healing in diabetic subjects.

show abstract

Nitric Oxide Regulates Wound Healing

Cited by 249 publications

References 1 publication

Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers

Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers

Effect of nebivolol on fracture healing: An experimental rat model

Effects of Polyglecaprone 25, Silk and Catgut Suture Materials on Oral Mucosa Wound Healing in Diabetic Rats: An Evaluation of Nitric Oxide Dynamics

Contact Info

Product

Resources

About