Nitric oxide, produced in the upper airways, may act in an ‘aerocrine’ fashion to enhance pulmonary oxygen uptake in humans

Lundberg, Jon O.; Settergren, G.; Alving, Kjell; Weitzberg, Eddie

doi:10.1111/j.1748-1716.1995.tb09998.x

Cited by 75 publications

(43 citation statements)

References 7 publications

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“…We aspirated NO-containing nasal air from the patient's nose and introduced this air into the inhalation limb of the ventilator. A significant fall in PVR and an increase in arterial oxygen tension (Pa,O 2 ) was seen when nasal air was added to the inhaled air [24,71]. This finding supports the hypothesis that inhaled NO, produced in the upper airways and then inhaled, may function as an aerocrine messenger involved in the regulation of pulmonary function in man.…”

Section: No As An Aerocrine Messengersupporting

confidence: 74%

Nitric oxide in exhaled air

Lundberg¹,

Weitzberg²,

Lundberg³

et al. 1996

Eur Respir J

137

112

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Much interest is now being focused on measurements of nitric oxide (NO) in exhaled air. In healthy subjects exhaled NO seems to originate mainly in the nasal airways, whereas the contribution from the lower respiratory tract is low.In certain inflammatory airway disorders, the excretion of NO into the airways is altered resulting in changes in the levels of NO in exhaled air. New techniques have been developed to measure NO release at different levels of the airways: asthmatics show increased orally-exhaled NO levels, whereas patients with cystic fibrosis or Kartagener' 's syndrome exhibit a marked reduction in nasal release of NO. It has been suggested that measurements of exhaled NO may be clinically useful in noninvasive diagnosis and monitoring of inflammatory airway diseases.To further evaluate the potential clinical usefulness of measurement of exhaled NO, it is vital to explore how airway NO production is normally regulated and what factors influence airway NO excretion.

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Section: No As An Aerocrine Messengersupporting

confidence: 74%

Nitric oxide in exhaled air

Lundberg¹,

Weitzberg²,

Lundberg³

et al. 1996

Eur Respir J

137

112

View full text Add to dashboard Cite

show abstract

“…NO is also a vasodilator and might contribute to mucosal swelling in, for example, rhinitis. NO has also been proposed as an ''aerocrine messenger'' between the nose and the lungs, in view of its capacity to improve oxygen uptake in the lower airways [15], although subsequent research has shown many other interactions between components of what is now known as the unified airway [16].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis

Dabholkar

Saberwal

Velankar

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Nitric oxide (NO) is a biological messenger produced by mammalian cells serving various functions including regulation of blood flow, platelet function, immunity, and neurotransmission. The paranasal sinuses and nasal mucosa are a major source of exhaled NO. The aim of the study is to compare the nasal NO (nNO) levels in patients with chronic rhinosinusitis with those of common cold patients and controls and to correlate CT scores with nNO levels. The nasal concentration of NO was measured by electroluminescence in 13 healthy volunteers, in 13 patients suffering from common cold and 13 patients with chronic rhinosinusitis. The concentration of NO was correlated with symptom scores, endoscopic findings and CT findings. The measured levels of NO did not differ between healthy volunteers and common cold patients, but they were significantly lower in patients suffering from chronic rhinosinusitis. As NO is a regulator of mucociliary activity and has bacteriostatic and antiviral effects, the decreased concentration of nNO in patients suffering from sinusitis suggests that lack of NO may contribute to the pathogenesis of this disease. Thus, nNO, which is easily measured, provides a valuable non-invasive objective measure of chronic rhinosinusitis.

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“…It has strong bacteriostatic and antiviral activities (1965,1966), in particular on rhinoviruses (1967,1968). It improves oxygenation (1969), exerts bronchodilatory activities (1970) and modulates lower airways responsiveness. 9.3.2.…”

Section: Commonalities and Differences In Mechanisms Between Rhinitismentioning

confidence: 99%