Nitric oxide (NO) involved in Cd tolerance in NHX1 transgenic duckweed during Cd stress

Ren, Qiuting; Li, Na; Liu, Ruxin; Ma, Xu; Sun, Jinge; Zeng, Jianyao; Li, Qingqing; Wang, Mingwei; Chen, Xinglin; Wu, Xiaoyu; Yang, Lin

doi:10.1080/15592324.2022.2065114

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Cadmium (Cd) is an environmental heavy metal that is one of the dangerous materials to food, water, soil, and animals 20 . Cd causes damage to various physiological and biochemical activities of organs or tissue in animals, such as hepatotoxicity, nephrotoxicity, cardiotoxicity, and pulmonotoxi 21–25 .…”

Section: Introductionmentioning

confidence: 99%

“…19 Cadmium (Cd) is an environmental heavy metal that is one of the dangerous materials to food, water, soil, and animals. 20 Cd causes damage to various physiological and biochemical activities of organs or tissue in animals, such as hepatotoxicity, nephrotoxicity, cardiotoxicity, and pulmonotoxi. [21][22][23][24][25] Cd from industrial contaminant can accumulate in the lung to impair resolution, but repeated inflammation causing chronic obstructive pulmonary disease (COPD).…”

Section: Introductionmentioning

confidence: 99%

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Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Tong

Guo

et al. 2023

Environmental Toxicology

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Cadmium (Cd) is an environmental heavy metal, and its accumulation is harmful to animal and human health. The cytotoxicity of Cd includes oxidative stress, apoptosis, and mitochondrial histopathological changes. Furthermore, polystyrene (PS) is a kind of microplastic piece derived from biotic and abiotic weathering courses, and has toxicity in various aspects. However, the potential mechanism of action of Cd co-treated with PS is still poorly unclear. The objective of this study was to investigate the effects of PS on Cd-induced histopathological injury of mitochondria in the lung of mice. In this study, the results have showed that Cd could induce the activity of oxidative enzymes of the lung cells in mice, increasing the content of partial microelement and the phosphorylation of inflammatory factor NF-κB p65. Cd further destroys the integrity of mitochondria by increasing the expression of apoptotic protein and blocking the autophagy. In addition, PS solely group aggravated the lung damage in mice, especially mitochondrial toxicity, and played a synergistic effect with Cd in lung injury. However, how PS can augment mitochondrial damage and synergism with Cd in lung of mice requiring further exploration. Therefore, PS was able to exacerbate Cd-induced mitochondrial damage to the lung in mice by blocking autophagy, and was associated with the apoptosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Tong

Guo

et al. 2023

Environmental Toxicology

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“…A method was devised that uses measures of in vitro hepatic biotransformation in animals to predict in vivo hepatic clearance [14]. This method has been applied to chemical risk assessment, evaluating medication candidates, and looking at idiosyncratic drug reactions.…”

mentioning

confidence: 99%

Perspective on Quantitative Structure–Toxicity Relationship (QSTR) Models to Predict Hepatic Biotransformation of Xenobiotics

Rai,

Paudel,

Sakhrie

et al. 2023

Livers

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Biotransformation refers to the metabolic conversion of endogenous and xenobiotic chemicals into more hydrophilic substances. Xenobiotic biotransformation is accomplished by a restricted number of enzymes with broad substrate specificities. The biotransformation of xenobiotics is catalyzed by various enzyme systems that can be divided into four categories based on the reaction they catalyze. The primary concentration is in cytochrome P450, while the CYP enzymes responsible for xenobiotic biotransformation are located within the hepatic endoplasmic reticulum (microsomes). Cytochrome P450 (CYP450) enzymes are also present in extrahepatic tissues. Enzymes catalyzing biotransformation reactions often determine the intensity and duration of the action of drugs and play a key role in chemical toxicity and chemical tumorigenesis. The structure of a given biotransforming enzyme may differ among individuals, which can cause differences in the rates of xenobiotic biotransformation. The study of the molecular mechanisms underlying chemical liver injury is fundamental for preventing or devising new modalities of treatment for liver injury using chemicals. Active metabolites arise from the biotransformation of a parent drug compound using one or more xenobiotic-processing enzymes to generate metabolites with different pharmacological or toxicological properties. Understanding how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determining the impact of these compounds on human health. Computational tools such as Biotransformer have been developed to predict all the possible metabolites of xenobiotic and enzymatic profiles that are linked to the production of metabolites. The construction of xenobiotic metabolism maps can predict enzymes catalyzing metabolites capable of binding to DNA.

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Bioinformatic and functional analysis of OsDHN2 under cadmium stress

Jiang,

Wang,

et al. 2023

Funct Integr Genomics

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Nitric oxide (NO) involved in Cd tolerance in NHX1 transgenic duckweed during Cd stress

Cited by 3 publications

References 23 publications

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Perspective on Quantitative Structure–Toxicity Relationship (QSTR) Models to Predict Hepatic Biotransformation of Xenobiotics

Bioinformatic and functional analysis of OsDHN2 under cadmium stress

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