Nitric Oxide Measurement in Chronic Cough

Lim, Kaiser G.

doi:10.1007/s00408-009-9187-x

Cited by 13 publications

(10 citation statements)

References 44 publications

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“…Fractional exhaled nitric oxide (FENO) is a biomarker of airway inflammation and it has been confirmed that several airway diseases such as asthma 1, 95–97, allergies 98–100, chronic cough 101, 102, atopic eczema 103, obstructive sleep apnea syndrome 104, and tuberculosis 105 are related to FENO level. In the past twenty years, FENO has been used as a useful clinical tool for diagnosis of airway diseases 106.…”

Section: Application Of No Electrochemical Sensorsmentioning

confidence: 99%

Electrochemical Sensors for Nitric Oxide Detection in Biological Applications

Scafa

et al. 2014

Electroanalysis

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Nitric oxide (NO) plays an important role in physiological processes and it has been confirmed some human diseases are related to its biological function. Electrochemical sensors provide an efficient way to explore the NO function in biological processes. This review details different kinds of electrochemical sensors used for NO concentration detection between 2008 and 2013 together with their application in biological samples. Four commonly used electrodes and different assisted analysis membranes used for contributions towards the development of the novel sensors were summarized. Electrochemical sensors employed to measure NO concentration in a single cell, cell culture, tissue homogenate, organ, in vivo, human being, as well as in plant were also detailed. The trends of developing novel NO sensors were outlooked in the last part.

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Section: Application Of No Electrochemical Sensorsmentioning

confidence: 99%

Electrochemical Sensors for Nitric Oxide Detection in Biological Applications

Scafa

et al. 2014

Electroanalysis

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“…In such patients with cough-variant asthma or EB, therapy exclusive of systemic steroids should be optimized by meticulous attention to ICS compliance and inhaler technique, environmental factors, etc. Measurement of exhaled nitric oxide can support the use of antiinflammatory therapy, as the presence of elevated exhaled nitric oxide levels is predictive of a favorable response to ICS [19]. 8.…”

Section: Clinical Observationsmentioning

confidence: 99%

Thoughts on One Thousand Chronic Cough Patients

Dicpinigaitis

2012

Lung

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Cough is the most common complaint for which patients seek medical attention. Although most cases of acute cough, due to viral upper respiratory tract infection, are transient and self-limited, chronic cough often poses a diagnostic and therapeutic challenge. A subgroup of patients suffering from chronic cough will elude a diagnosis despite appropriate evaluation, and will prove refractory to all therapeutic intervention. Having personally evaluated 1000 individuals presenting to a specialty cough center, the author shares insights regarding the demographic composition of this unique group of patients, as well as clinical observations and opinions on currently unmet needs requiring further research.

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“…Recently, exhaled nitric oxide has been proposed as a useful biomarker to confirm the presence of eosinophilic airway inflammation and thus, predict a favourable response to inhaled corticosteroid therapy in both asthmatic cough as well as cough due to non‐asthmatic eosinophilic bronchitis (Lim, 2010). Absence of a response to systemic corticosteroids should prompt evaluation for other aetiologies of chronic cough.…”

Section: Chronic Coughmentioning

confidence: 99%

Cough: an unmet clinical need

Dicpinigaitis

2011

British J Pharmacology

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Cough is among the most common complaints for which patients worldwide seek medical attention. Thus, the evaluation and treatment of cough result in tremendous financial expenditure and consumption of health care resources. Yet, despite the clinical significance of cough, research efforts aimed at improving diagnostic capabilities and developing more effective therapeutic agents have been, to date, disappointing in their limited scope and outcomes. Acute cough due to the common cold represents the most common type of cough. Currently, available medications for the symptomatic management of acute cough are inadequate due to lack of proven efficacy and/or their association with undesirable or intolerable side effects at anti-tussive doses. Subacute cough, often representing a prolonged post-viral response, is typically refractory to standard anti-tussive therapy. Few clinical trials have evaluated therapeutic options for subacute cough. Diagnostic challenges facing the clinician in the management of chronic cough include the determination of whether symptoms of upper airway cough syndrome (formerly, postnasal drip syndrome) or gastro-oesophageal reflux disease are indeed the underlying cause of cough. Chronic, refractory unexplained (formerly, idiopathic) cough must be distinguished from cough that has not been fully evaluated and treated according to current guideline recommendations. Eagerly awaited are new safe and effective anti-tussive agents for use when cough suppression is desired, regardless of underlying aetiology of cough, as well as practical, validated ambulatory cough counters to aid clinical assessment and future research in the field of cough.

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Nitric Oxide Measurement in Chronic Cough

Cited by 13 publications

References 44 publications

Electrochemical Sensors for Nitric Oxide Detection in Biological Applications

Electrochemical Sensors for Nitric Oxide Detection in Biological Applications

Thoughts on One Thousand Chronic Cough Patients

Cough: an unmet clinical need

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