Nitric oxide for preventing pre-eclampsia and its complications

Abstract

There is insufficient evidence to draw reliable conclusions about whether nitric oxide donors and precursors prevent pre-eclampsia or its complications.

Evaluation of Nitric Oxide Concentrations in Preeclampsia and Normal Pregnancy

“…drugs, like glycerol trinitrate, or their precursors, like L-arginine, may play a role in helping to prevent preeclampsia through their action in relaxing blood vessel walls. [2] Serum nitrite levels were higher in preeclamptic women (34.11±14 ¼mol/l, P=0.04), lower in chronic hypertensive women (19.56±6.46 ¼mol/l, P=0.04) and similar in women with gestational hypertension (26.97±9.44 ¼mol/l) in comparison to the control group (25.37±7.24 ¼mol/l). [3] Circulating levels of nitrite are decreased in patients with preeclampsia.…”

Evaluation of Nitric Oxide Concentrations in Preeclampsia and Normal Pregnancy

“…drugs, like glycerol trinitrate, or their precursors, like L-arginine, may play a role in helping to prevent preeclampsia through their action in relaxing blood vessel walls. [2] Serum nitrite levels were higher in preeclamptic women (34.11±14 ¼mol/l, P=0.04), lower in chronic hypertensive women (19.56±6.46 ¼mol/l, P=0.04) and similar in women with gestational hypertension (26.97±9.44 ¼mol/l) in comparison to the control group (25.37±7.24 ¼mol/l). [3] Circulating levels of nitrite are decreased in patients with preeclampsia.…”

Endothelial Cell Vasodilator Dysfunction Mediates Progressive Pregnancy-induced Hypertension in Endothelial Cell Tetrahydrobiopterin Deficient Mice

“…Markers of oxidative stress are present in the placenta and maternal circulation of patients with pre-eclampsia (Raijmakers, Dechend & Poston, 2004) and we have previously shown reduced BH4 in placental extravascular vesicles from women with hypertensive pregnancies (Chuaiphichai et al, 2021). Yet in a landmark clinical trial the antioxidant vitamins C and E failed to prevent the development of pre-eclampsia in high risk pregnancies (Poston, Briley, Seed, Kelly & Shennan, 2006), and simple strategies attempting to restore or augment NO with NO donors in pre-eclampsia have been disappointing (Meher & Duley, 2007). One possible explanation for these results is the failure to specifically target eNOS uncoupling and consequent altered NO/ROS signalling.…”

Asymmetric Dimethylarginine in the Maternal and Fetal Circulation in Preeclampsia

“…Oral L-arginine supplementation was investigated by our group; the intervention did not alter blood pressure in preeclampsia (32). A recent review found that evidence is still insufficient to draw reliable conclusions as to whether L-arginine can prevent preeclampsia or its complications (33). Interestingly, a study involving dietary supplementation with 3 g/d L-arginine found no difference in biochemical markers, but supplementation significantly decreased maternal blood pressure and improved fetal outcome (34,35).…”

Evaluation of Nitric Oxide Concentrations in Preeclampsia and Normal Pregnancy

“…drugs, like glycerol trinitrate, or their precursors, like L-arginine, may play a role in helping to prevent preeclampsia through their action in relaxing blood vessel walls. [2] Serum nitrite levels were higher in preeclamptic women (34.11±14 ¼mol/l, P=0.04), lower in chronic hypertensive women (19.56±6.46 ¼mol/l, P=0.04) and similar in women with gestational hypertension (26.97±9.44 ¼mol/l) in comparison to the control group (25.37±7.24 ¼mol/l). [3] Circulating levels of nitrite are decreased in patients with preeclampsia.…”

Endothelial Cell Vasodilator Dysfunction Mediates Progressive Pregnancy-induced Hypertension in Endothelial Cell Tetrahydrobiopterin Deficient Mice

“…Markers of oxidative stress are present in the placenta and maternal circulation of patients with pre-eclampsia (Raijmakers, Dechend & Poston, 2004) and we have previously shown reduced BH4 in placental extravascular vesicles from women with hypertensive pregnancies (Chuaiphichai et al, 2021). Yet in a landmark clinical trial the antioxidant vitamins C and E failed to prevent the development of pre-eclampsia in high risk pregnancies (Poston, Briley, Seed, Kelly & Shennan, 2006), and simple strategies attempting to restore or augment NO with NO donors in pre-eclampsia have been disappointing (Meher & Duley, 2007). One possible explanation for these results is the failure to specifically target eNOS uncoupling and consequent altered NO/ROS signalling.…”

Asymmetric Dimethylarginine in the Maternal and Fetal Circulation in Preeclampsia

“…Oral L-arginine supplementation was investigated by our group; the intervention did not alter blood pressure in preeclampsia (32). A recent review found that evidence is still insufficient to draw reliable conclusions as to whether L-arginine can prevent preeclampsia or its complications (33). Interestingly, a study involving dietary supplementation with 3 g/d L-arginine found no difference in biochemical markers, but supplementation significantly decreased maternal blood pressure and improved fetal outcome (34,35).…”

Evaluation of Nitric Oxide Concentrations in Preeclampsia and Normal Pregnancy

“…drugs, like glycerol trinitrate, or their precursors, like L-arginine, may play a role in helping to prevent preeclampsia through their action in relaxing blood vessel walls. [2] Serum nitrite levels were higher in preeclamptic women (34.11±14 ¼mol/l, P=0.04), lower in chronic hypertensive women (19.56±6.46 ¼mol/l, P=0.04) and similar in women with gestational hypertension (26.97±9.44 ¼mol/l) in comparison to the control group (25.37±7.24 ¼mol/l). [3] Circulating levels of nitrite are decreased in patients with preeclampsia.…”

Endothelial Cell Vasodilator Dysfunction Mediates Progressive Pregnancy-induced Hypertension in Endothelial Cell Tetrahydrobiopterin Deficient Mice

“…Markers of oxidative stress are present in the placenta and maternal circulation of patients with pre-eclampsia (Raijmakers, Dechend & Poston, 2004) and we have previously shown reduced BH4 in placental extravascular vesicles from women with hypertensive pregnancies (Chuaiphichai et al, 2021). Yet in a landmark clinical trial the antioxidant vitamins C and E failed to prevent the development of pre-eclampsia in high risk pregnancies (Poston, Briley, Seed, Kelly & Shennan, 2006), and simple strategies attempting to restore or augment NO with NO donors in pre-eclampsia have been disappointing (Meher & Duley, 2007). One possible explanation for these results is the failure to specifically target eNOS uncoupling and consequent altered NO/ROS signalling.…”

Asymmetric Dimethylarginine in the Maternal and Fetal Circulation in Preeclampsia

“…Oral L-arginine supplementation was investigated by our group; the intervention did not alter blood pressure in preeclampsia (32). A recent review found that evidence is still insufficient to draw reliable conclusions as to whether L-arginine can prevent preeclampsia or its complications (33). Interestingly, a study involving dietary supplementation with 3 g/d L-arginine found no difference in biochemical markers, but supplementation significantly decreased maternal blood pressure and improved fetal outcome (34,35).…”