NIR light controlled release of caged hydrogen sulfide based on upconversion nanoparticles

Chen, Wansong; Chen, Min; Zang, Qiguang; Wang, Liqiang; Tang, Feiying; Han, Yuge; Yang, Cejun; Liu, Deng; Liu, You-Nian

doi:10.1039/c5cc02508g

Cited by 54 publications

(47 citation statements)

References 17 publications

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“…[15c,22] The active sulfur anions can bind Cu 2+ , leading to the color change. To investigate the disruption process of disulfide bonds under alkaline condition, a probe for sulfur anions, DNS‐Az, was utilized to monitor the reaction between BSA and alkali . As shown in Figure b, only negligible emission is observed when incubating DNS‐Az with buffer solution (PBS, 10 × 10 −3 m , 7.4) or BSA.…”

Section: Resultsmentioning

confidence: 99%

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Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

Sheng

Wang

Han

et al. 2017

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124

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Fabrication of clinically translatable nanoparticles (NPs) as photothermal therapy (PTT) agents against cancer is becoming increasingly desirable, but still challenging, especially in facile and controllable synthesis of biocompatible NPs with high photothermal efficiency. A new strategy which uses protein as both a template and a sulfur provider is proposed for facile, cost‐effective, and large‐scale construction of biocompatible metal sulfide NPs with controlled structure and high photothermal efficiency. Upon mixing proteins and metal ions under alkaline conditions, the metal ions can be rapidly coordinated via a biuret‐reaction like process. In the presence of alkali, the inert disulfide bonds of S‐rich proteins can be activated to react with metal ions and generate metal sulfide NPs under gentle conditions. As a template, the protein can confine and regulate the nucleation and growth of the metal sulfide NPs within the protein formed cavities. Thus, the obtained metal sulfides such as Ag2S, Bi2S3, CdS, and CuS NPs are all with small size and coated with proteins, affording them biocompatible surfaces. As a model material, CuS NPs are evaluated as a PTT agent for cancer treatment. They exhibit high photothermal efficiency, high stability, water solubility, and good biocompatibility, making them an excellent PTT agent against tumors. This work paves a new avenue toward the synthesis of structure‐controlled and biocompatible metal sulfide NPs, which can find wide applications in biomedical fields.

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Section: Resultsmentioning

confidence: 99%

“…Synthesis of Dansyl Azide (DNS‐Az) : DNS‐Az was synthesized according to our previous work. [23a] In detail, DNS‐Cl (0.135 g, 0.5 mmol) was dissolved in 10 mL ethanol, then 10 mL NaN 3 (0.065 g, 1 mmol) aqueous solution was added. TLC was utilized to monitor the reaction.…”

Section: Methodsmentioning

confidence: 99%

Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

Sheng

Wang

Han

et al. 2017

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124

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“…Photolytic gas release is broadly applicable to various gas molecules that include carbon monoxide (CO), [199] sulfur dioxide (SO 2 ), [175] and hydrogen sulfide (H 2 S). [200,201] CO release is achieved using a manganese carbonyl complex with ability to undergo Mn-CO dissociation by irradiation at 365 nm. [199] This Mn-CO complex was used for NIR-responsive CO delivery by its loading in polymer-coated UCN as reported by Pierri et al [199] Such NIR approach was also applied for SO 2 delivery using UCN@mSiO 2 loaded with thiophene-1,1-dioxide as the SO 2 precursor ( Figure 7C).…”

Section: Gas Molecules Of Biological Significancementioning

confidence: 99%

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

Choi

2020

Advanced Therapeutics

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Control of therapeutic release constitutes one of most critical aspects considered in the design of nanoscale delivery systems. There are a variety of cellular factors and external stimuli employed for release control. Of these, use of light offers various photoactivation mechanisms that enable to effectively engage in therapeutic release. It also allows a higher degree of spatial and temporal control. Over recent decades, the application of photoactivation strategies has seen remarkable growth and made a significant impact on rapid advances in the field of drug delivery. This Review aims to summarize the fundamental concepts and practical applications demonstrated recently in numerous therapeutic areas from cancers to infectious diseases. Its scope is defined by a focus on those photoactivation strategies that occur via either linker cleavage, nanocontainer gating, or disassembly. Each of these is discussed with specific examples and underlying mechanisms that comprise linker photolysis, photoisomerization, photothermal heating, or photodynamic reactions with reactive oxygen species. In summary, this Review provides an inclusive summary of new developments and insights obtained from recent progress in photoactivation strategies and their applications in therapeutic nanodelivery.

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“…The first such donors were reported by Xian et al utilizing o-nitrobenzyl protection.T hese donors (16,S cheme 11)w ere triggered by UV light (365 nm). [31] Near IR light-activated nanoparticles, [32] nitroreductase-activated donors (17), [33] and thiol-activated donors (18) [34] based on this platform werealso reported. It should be noted that H 2 Sr eleasef rom these donors is controlled by both ÀSH deprotection and the hydrolysis of gem-dithiols.…”

Section: Scheme10mentioning

confidence: 99%

Strategies for the Design of Donors and Precursors of Reactive Sulfur Species

Hamsath

Neill

et al. 2018

Chemistry A European J

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Reactive sulfur species (RSS) play regulatory roles in biological systems. Many RSS are highly reactive and transient molecules, making their study difficult. RSS donors or precursors, which are used to specifically produce or deliver RSS, are useful research tools, as well as possible therapeutic agents. In this Minireview, we summarized the chemical strategies that have been used in the design of donors/precursors of hydrogen sulfide relevant RSS (including hydrogen sulfide, hydrogen polysulfides, persulfides, and S‐nitroso‐hydrogen sulfide). The potential problems of applying these strategies in biological settings are also discussed.

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NIR light controlled release of caged hydrogen sulfide based on upconversion nanoparticles

Cited by 54 publications

References 17 publications

Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

Strategies for the Design of Donors and Precursors of Reactive Sulfur Species

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