NIR-II responsive PEGylated nickel nanoclusters for photothermal enhanced chemodynamic synergistic oncotherapy

Abstract

Rationale: All kinds of non-metal and metal-based nanozymes have been extensively explored as Fenton agents for Chemodynamic therapy (CDT). However, the low catalytic efficiency of non-metallic nanozymes and the susceptibility to oxidation and long-term toxicity of metallo-nanozymes limit their potential in CDT. Methods: In this study, we report a magneto-solvothermal method to tune the crystallinity and shape of polyethylene glycol (PEG)-ylated urchin-like nickel nanoclusters (named as 9T-PUNNC) at a high magnetic field with an intensity of 9 T for enhanced combined photothermal-chemodynamic therapy. Results:The needle-like protrusions on the surface of 9T-PUNNC can effectively increase the reception of NIR light in second NIR window (NIR-II) and transform it into local hyperthermia, achieving effective photothermal treatment. The light and heat generated by NIR-II further promotes the release of Ni 2+ and improves the ability of Ni 2+ -mediated chemodynamic therapy (CDT). In addition, the surface coating of PEG on the surface of 9T-PUNNC improves its stability and biocompatibility of nanocrystals. In vitro and in vivo results indicate that the 9T-PUNNC could efficiently kill tumor cells (nearly 12 times more than control group) and inhibit tumor growth (nearly 9 times smaller than control group) under NIR-II irradiation through the synergistic effect of combined treatments. Conclusions: we developed a novel synthetic strategy to tune crystallinity and shape of PUNNC for enhanced NIR-II responsive photothermal conversion efficiency and accelerated acid-induced dissolution for improved •OH generation. Such 9T-PUNNC enable a combined chemodynamic-photothermal treatment to provide superior therapeutic efficacy due to their highly synergistic effect.

Multifunctional biocompatible Ni/Ni–P nanospheres for anti-tumor “neoadjuvant phototherapy” combining photothermal therapy and photodynamic therapy

“…For example, the photothermal conversion efficiency of NiPPD NPs is only 18.5% under an 808 nm laser and 9T-PUNNC is 20.93% under 1064 nm. 32,33 It is almost similar to other nickel elemental photothermal agents, such as Ni-based metal-organic framework (complex 1, 10.75%, 660 nm), 34 NPs [Ni4C 12 ] (26%, 940 nm), 35 and NiO NPs@AuNPs@Van (30%, 808 nm). 36 In addition, compared with the photothermal agents with the property of absorbing at 808 nm including MoS 2 -Cys (35%), 37 PPy vesicles (24.2%) 38 and PVP-Bi (30%), 39 NNPIP NPs still have an advantage in terms of photothermal conversion efficiency (Table S1, ESI †).…”

Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy

“…6 g and Additional file 1 : Fig. S16) [ 47 , 48 ]. To further assess the long-term biosafety of AuNDs, hemolysis experiment, blood routine and serum biochemistry assay were carried out.…”

Facile Synthesis of Basic Copper Carbonate Nanosheets for Photoacoustic Imaging-Guided Tumor Apoptosis and Ferroptosis and the Extension Exploration of the Synthesis Method

“…Due to their good biosafety and unique properties, transition metal ion-based carbonate nanomaterials are showing great potential in biomedical fields. − To date, transition metal ions, such as Cu, Fe, Mn, and Co, have been developed as Fenton or Fenton-like agents to eliminate malignant tumors through CDT. ,− The combination of these ions is expected to enhance ROS production capacity …”