Nine days extended release of adenosine from biocompatible MOFs under biologically relevant conditions

El-Mehalmey, Worood A.; Latif, Najma; Ibrahim, Ahmed; Haikal, Rana R.; Mierzejewska, Paulina; Smoleński, Ryszard T.; Yacoub, Magdi H.; Alkordi, Mohamed H.

doi:10.1039/d1bm01519b

Cited by 6 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Fig. 2 a, absorption bands at 680 cm −1 and at 1510 cm −1 were observed due to stretching vibrations in the Zr–O bond and C C bond in benzene ring [ 48 ]. Moreover, the peaks at 1395 cm −1 and 1590 cm −1 , respectively, reflected the symmetrical and unsymmetrical stretching vibrations in the C C–O bond of H 2 BDC.…”

Section: Resultsmentioning

confidence: 99%

“…UiO-66 is considered a prominent MOF, which is synthesized using a zirconium oxide complex [Zr 6 O 4 (OH) 4 bridged by 1,4-benzene dicarboxylic acid ligands (H 2 BDC) [ 45 ]. In addition to possessing typical advantages observed in most MOFs, such as a large specific surface area, high porosity, and the presence of catalytically active sites [ 46 ], UiO-66 distinguishes itself due to its notable attributes of low toxicity and exceptional mechanical, thermal, acidic, and aqueous stability [ 47 , 48 ]. The inherent stability of UiO-66 allows for more flexible incorporation of various functionalizations [ [49] , [50] , [51] ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

Liu,

Wu,

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

Liu,

Wu,

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

“…Good biocompatibility means that MOF materials will not cause obvious toxic reactions, immune reactions or tissue damage. [ 41 ] The biocompatibility of MOF materials can be evaluated by in vitro and in vivo biocompatibility tests, such as cytotoxicity test, cell adhesion and proliferation evaluation, and animal experiments. For example, ZIF‐8 and UiO‐66 have been proven to have good biocompatibility in cell experiments and animal models, and can be successfully applied to nerve repair in vivo as DDS.…”

Section: Biological Characteristics Of Mofsmentioning

confidence: 99%

Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy

Meng,

Ren,

Dong

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Recently, neurological disorders have led to a growing global burden of fatalities and disabilities. The limited capacity for natural self‐regeneration poses a significant challenge in repairing nervous system injuries, which is closely related to the complex microenvironment and nonregenerative nature of neurons. Metal–organic frameworks (MOFs), with their distinctive structure and properties including high surface area, porosity, tunability, stimuli‐responsive behavior, biocompatibility, and biodegradability, stand as an auspicious platform for devising therapeutic strategies aiming at nerve regeneration and repair. By taking advantage of these characteristics, researchers have the opportunity to explore innovative methods including endogenous stimulation, magnetic response therapy, phototherapy, ultrasound therapy, and drug delivery systems for the treatment of neurological diseases. Moreover, MOFs‐based stem cell therapy also is developed to inhibit neuroinflammation and oxidative stress, promote axon growth, regulate stem cell differentiation, promote nerve regeneration, and finally restore the function of injured nerves. In this paper, the preparation strategy and biological characteristics of MOFs, highlighting their applications in repairing nerve injuries and treating neural stem cells is presented. Finally, an outlook on the future development and challenges in the field of neuroscience concerning MOFs is provided.

show abstract

“…The result illustrates that nanoscale Zr-MOFs are beneficial for controllable drug delivery and release using nano-Zr-MOFs-based nanocarriers. Meanwhile, other Zr-MOFs, including PCN-222 and UiO-66-COOH, have been prepared to deliver different drugs [105][106][107][108][109][110]. According to these investigations, functional groups are easily introduced in organic linkers to affect the particle size of MOFs, the cytotoxicity, and the drug-carrying capacity.…”

Section: Zr-based Uiosmentioning

confidence: 99%

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

et al. 2022

View full text Add to dashboard Cite

Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years. Meanwhile, some representative examples are highlighted in detail according to four categories, including the University of Oslo MOFs, Fe-MOFs, cyclodextrin MOFs, and other MOFs. Moreover, the opportunities and challenges of MOF-based smart delivery vehicles are discussed. We hope that this review will be helpful for researchers to understand the recent developments and challenges of MOF-based drug-delivery systems.

show abstract

Nine days extended release of adenosine from biocompatible MOFs under biologically relevant conditions

Cited by 6 publications

References 36 publications

Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

Contact Info

Product

Resources

About