Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys

Bayrak, Ömer; Bavbek, Nüket; Karataş, Ömer Faruk; Bayrak, Reyhan; Çatal, Ferhat; Çimentepe, Ersin; Akbaş, Ali; Yildirim, Erol; Unal, Dogan; Akçay, Ali

doi:10.1093/ndt/gfm953

Cited by 73 publications

(49 citation statements)

References 31 publications

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“…The polymer is far less toxic but retains much of the pharmacologic properties of TQ, which is the active principle of the plant. The pharmacological actions of the seeds of Nigella sativa or its constituents that have been reported include protection against nephrotoxicity and hepatotoxicity induced by either disease or chemicals [6][7][8][9][10][11][12][13][14]. The seeds/oil have anti-inflammatory [15], analgesic [4], antipyretic [16], spasmolytic [17], bronchodialator [17], antihistaminic [18], antihypertensive [19], antitumor [20], antioxidant [18], antineoplastic [9,21,22], antifertility [23], antibacterial [24], antifungal [25], antiprotozoal [26], anthelmintic [27] and insecticidal [28] activities.…”

Section: Review and Discussionmentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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Section: Review and Discussionmentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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“…The majority of studies that have been performed to evaluate the different effects of NS have been confined to address its antitoxic properties [9,10,26,27]. In addition to this, many investigators have determined the antioxidant activities of NS in vivo [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…The seeds or oil of Nigella sativa (NS), belonging to the Ranunculaceae family, commonly known as black seed or black cumin, have been used as a natural remedy for a number of diseases and conditions such as asthma, cough, bronchitis, headache, eczema, fever, dizziness and influenza [6]. NS contains >30 w/w of fixed oil and 0.45 w/w of a volatile oil.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effects of <i>Nigella Sativa</i> in the Treatment of Experimentally Induced Rhinosinusitis

Yörük¹,

Gür²,

Uyanik³

et al. 2010

Macedonian Journal of Medical Sciences

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Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental bacterial rhinosinusitis. Material and Methods.Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into control, NS 50, NS 100 and NS 200 mg/kg/d groups. NS was given orally for 7 days. The same volume of normal saline was given as a vehicle to the control group for the same period. At 7 days post-treatment, mucosal samples were excised from the treated and control groups for measurements of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), myeloperoxidase (MPO) and malondialdehyde (MDA). Conclusion. These findings show that administration of NS increased the SOD, GSH-Px activities and decreased the lipid peroxidation and MPO activity in experimental rhinosinusitis in rabbits. NS prevented oxidative stress by scavenging reactive oxygen species generated in rhinosinusitis model in rabbits. Results. SOD and GSH-Px activities significantly increased in the NS

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“…Second, it detoxifies the free radicals action by either acting itself as antioxidant or indirectly by significantly improving serum enzymatic activities of SOD, GSH peroxidase, and CAT thus further augmenting the antioxidant mechanism. 43,44 Further preclinical and clinical studies are required to confirm and elucidate the protective effect of N. sativa against NSAIDs induced damages.…”

Section: 39mentioning

confidence: 99%