1963
DOI: 10.1001/archderm.1963.01590160037006
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Nicotinic Acid and Ethyl Nicotinate in Excised Human Skin

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Cited by 18 publications

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“…This structure and its unique, encompassing solubility characteristics cannot adequately be duplicated over the full range of polarity by any lipophilic solvent. For this reason attempts to predict skin permeability from limited correlations found with olive oil: water partition coefficients proved unsuccessful (11,39,43,181,183,216).…”
Section: Steady-state Permeability Of Skin-fick's Lawmentioning
confidence: 99%
“…These differences occur not because of, but despite the intrinsic differences in diffusivity; they are due primarily to differences in thickness. Several observations have been reported in the literature and incorrect inferences drawn because of a failure to wait for steady-state diffusion to develop (43,56).…”
Section: Regional Variations In Permeabilitymentioning
confidence: 99%
“…There appear to be many instances where the extremely small amounts of material capable of entering skin quickly via shunt pathways have demonstrable physiological effects (1,43,150).…”
Section: Concentration Levels In the Skinmentioning
confidence: 99%
See 2 more Smart Citations
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This structure and its unique, encompassing solubility characteristics cannot adequately be duplicated over the full range of polarity by any lipophilic solvent. For this reason attempts to predict skin permeability from limited correlations found with olive oil: water partition coefficients proved unsuccessful (11,39,43,181,183,216).…”
Section: Steady-state Permeability Of Skin-fick's Lawmentioning
confidence: 99%
“…These differences occur not because of, but despite the intrinsic differences in diffusivity; they are due primarily to differences in thickness. Several observations have been reported in the literature and incorrect inferences drawn because of a failure to wait for steady-state diffusion to develop (43,56).…”
Section: Regional Variations In Permeabilitymentioning
confidence: 99%
“…There appear to be many instances where the extremely small amounts of material capable of entering skin quickly via shunt pathways have demonstrable physiological effects (1,43,150).…”
Section: Concentration Levels In the Skinmentioning
confidence: 99%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.