1963
Nicotinic Acid and Ethyl Nicotinate in Excised Human Skin
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1963
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Cited by 18 publications
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“…This structure and its unique, encompassing solubility characteristics cannot adequately be duplicated over the full range of polarity by any lipophilic solvent. For this reason attempts to predict skin permeability from limited correlations found with olive oil: water partition coefficients proved unsuccessful (11,39,43,181,183,216).…”
Section: Steady-state Permeability Of Skin-fick's Lawmentioning
confidence: 99%
“…This structure and its unique, encompassing solubility characteristics cannot adequately be duplicated over the full range of polarity by any lipophilic solvent. For this reason attempts to predict skin permeability from limited correlations found with olive oil: water partition coefficients proved unsuccessful (11,39,43,181,183,216).…”
Section: Steady-state Permeability Of Skin-fick's Lawmentioning
confidence: 99%
“…These differences occur not because of, but despite the intrinsic differences in diffusivity; they are due primarily to differences in thickness. Several observations have been reported in the literature and incorrect inferences drawn because of a failure to wait for steady-state diffusion to develop (43,56).…”
Section: Regional Variations In Permeabilitymentioning
confidence: 99%
