J. Neurosci. Res. volume 87, issue 4, P937-947 2009 DOI: 10.1002/jnr.21901 View full text
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Mee-Young Lee, Lei Chen, Michal Toborek

Abstract: Primary impact to the spinal cord results in stimulation of secondary processes that potentiate the initial trauma. In the present study, we hypothesized that the altered expression of nitric oxide synthase (NOS) may contribute to these effects. Recent evidence indicates that nicotine can exert potent antioxidant and neuroprotective effects in spinal cord injury (SCI). Therefore, the aim of the present study was to evaluate whether the administration of nicotine can influence expression of inducible NOS (iNOS)…

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