2003
DOI: 10.1038/nature01578
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Abstract: Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon, including decreased oxidative damage and altered energy metabolism. In Saccharomyces cerevisiae, lifespan extension by calorie restriction requires the NAD+-dependent histone deacetylase, Sir2 (ref. 1). We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamid… Show more

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Cited by 656 publications
(663 citation statements)
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“…NAMPT has a crucial role for growth factor-induced myeloid differentiation (Skokowa et al, 2009), circadian clock (Nakahata et al, 2009;Ramsey et al, 2009), glucose-restriction-impaired skeletal myoblast differentiation (Fulco et al, 2008) and insulin secretion in pancreatic beta cells (Revollo et al, 2007). Overexpression of NAMPT extends lifespan of human vascular smooth muscle cells (van der Veer et al, 2007), resembling the effect of yeast NAD þ salvage pathway gene PNC1 for promoting longevity (Anderson et al, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…NAMPT has a crucial role for growth factor-induced myeloid differentiation (Skokowa et al, 2009), circadian clock (Nakahata et al, 2009;Ramsey et al, 2009), glucose-restriction-impaired skeletal myoblast differentiation (Fulco et al, 2008) and insulin secretion in pancreatic beta cells (Revollo et al, 2007). Overexpression of NAMPT extends lifespan of human vascular smooth muscle cells (van der Veer et al, 2007), resembling the effect of yeast NAD þ salvage pathway gene PNC1 for promoting longevity (Anderson et al, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…The involvement of sirt1 in life span extension by CR may relate to its responsiveness to nicotinamide levels and the NAD + :NADH ratio, both indicators of cellular energy status (72,73). Activation of sirt1, the mammalian homolog of an NAD + -dependent deacetylase known to modulate life span in lower organisms (74,75), is thought to hold promise as a strategy for delaying aging in mammals (76).…”
Section: Sirtuin Activatorsmentioning
confidence: 99%
“…The gene began to draw wider attention when it showed a positive function in life span control (Anderson et al, 2003;Guarente and Kenyon, 2000;Lin et al, 2000). The similar effect on life span elongation has been demonstrated with nematode, fruit fly, and mammalian cells by molecular approaches (Cohen et al, 2004).…”
Section: Introductionmentioning
confidence: 88%