Nickel(II) and zinc(II) dimonensinates: Single crystal X-ray structure, spectral properties and bactericidal activity

Cytotoxicity of Monensic Acid and its Biometal(II) Complexes Against Anaerobic Bacterial StrainClostridium PerfringensSpp.

“…the complexes of ni(ii) (5) and Zn(ii) (6) are effective against B. subtilis, B. mycoides and C. perfringens, although they do Pantcheva et al (7,8,9,10) B. mycoides c Pantcheva et al (7,8,9,10) not show toxicity against S. lutea in the studied concentration range. notably, the Mn(ii) complex (4) was shown to be the least toxic among the metal(ii) compounds against Gram-positive aerobic bacteria.…”

“…Monensic acid (Monh) and its biometal(ii) complexes with ions of Mg(ii), ca(ii), co(ii), Mn(ii), ni(ii) and Zn(ii) were prepared as previously reported (8,9,10). their structural characteristics have also been previously described (8,9,10).…”

“…in this respect we have recently studied the ability of these antibiotics, especially Monensin, to coordinate divalent bio-and toxic metal ions. We were able to characterize complexes of various compositions and different structures depending on the antibiotic applied (acidic or sodium form) as well as on the metal(ii) ion tested (7,8,9,10). our studies revealed that the activity of metal(ii) complexes of Monensin and Salinomycin is enhanced compared to the non-coordinated antibiotics against Gram-positive aerobic bacteria.…”

“…For comparative purposes, data obtained using Grampositive aerobic bacteria are also included (7,8,9,10). the bacterial assay showed that metal(ii) salts are ineffective by themselves and do not affect the growth of aerobic and anaerobic microorganisms.…”

Structure of 1:1 complex of 1-naphthylmethyl ester of monensin A with sodium perchlorate studied by X-ray, FT-IR and ab initio methods

“…Over the last decade, extensive X-ray crystallographic and spectroscopic studies of the three-dimensional structure of monensin salts [11][12][13][14][15][16][17][18][19], monensin derivatives [20][21][22] and their complexes with monovalent [23][24][25][26][27][28][29][30][31] and divalent cations [32][33][34] have taken us to a new level of understanding of the mechanism and function of the ionophoric antibiotics. Among the new remarkable features revealed by structural studies, is the proton channel formation by monensin A methyl ester [35], complexation of divalent cation by monensin [14][15][16][17][18][19] and its derivatives [32][33][34].…”