2006
DOI: 10.1093/nar/gkl830
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Abstract: Activation-induced cytidine deaminase (AID) likely initiates immunoglobulin gene-conversion (GC) by deaminating cytidines within the V-region of chicken B-cells. However, the intervening DNA lesion required to initiate GC remains elusive. GC could be initiated by a single strand break or a double strand break (DSB). To distinguish between these possibilities, we examined GC in the chicken DT40 B cell line deficient in non-homologous end joining (NHEJ). It is known that the NHEJ and homologous recombination DNA… Show more

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Cited by 20 publications
(27 citation statements)
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“…This is further confirmed by the fact that AID attacks C on both strands simultaneously (67). AID-initiated DSBs are the intermediates in IgV L SHM and GCV (12,19,26,53), and HR and NHEJ are the two conserved main pathways evolved to deal with DNA breaks, from yeast to vertebrates. HR plays a dominant role in DSB repair in yeast, whereas NHEJ is the predominant repair mechanism in vertebrates, including birds.…”
Section: Discussionmentioning
confidence: 70%
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“…This is further confirmed by the fact that AID attacks C on both strands simultaneously (67). AID-initiated DSBs are the intermediates in IgV L SHM and GCV (12,19,26,53), and HR and NHEJ are the two conserved main pathways evolved to deal with DNA breaks, from yeast to vertebrates. HR plays a dominant role in DSB repair in yeast, whereas NHEJ is the predominant repair mechanism in vertebrates, including birds.…”
Section: Discussionmentioning
confidence: 70%
“…DNA-PKcs suppresses both spontaneous and DSB-induced HR at the initial step of DNA repair (56). This was clearly demonstrated by its suppression of GCV in DT40 cells (19,53). The promotion of GCV/HR by GANP (Fig.…”
Section: Discussionmentioning
confidence: 90%
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