NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis

Pflug, Kathryn M.; Lee, Dong W.; Keeney, Justin; Sitcheran, Raquel

doi:10.1016/j.bbadis.2023.166682

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Non-canonical Nf-κb Pathway1

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2023

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“…NIK interacts with and activates both IKKα and IKKβ, phosphorylating IKKα to a greater extent. Consequently, NIK acts as an upstream kinase for the IKK complex, facilitating signaling from multiple cytokine receptors [63][64][65]. Several other kinases, including MEKK1 and TAK1, were identified as IKK kinases, sometimes acting alongside NIK.…”

Section: Non-canonical Nf-κb Pathwaymentioning

confidence: 99%

The Yin and Yang of IκB Kinases in Cancer

Abdrabou

2023

Kinases and Phosphatases

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IκB kinases (IKKs), specifically IKKα and IKKβ, have long been recognized for their pivotal role in the NF-κB pathway, orchestrating immune and inflammatory responses. However, recent years have unveiled their dual role in cancer, where they can act as both promoters and suppressors of tumorigenesis. In addition, the interplay with pathways such as the MAPK and PI3K pathways underscores the complexity of IKK regulation and its multifaceted role in both inflammation and cancer. By exploring the molecular underpinnings of these processes, we can better comprehend the complex interplay between IKKs, tumor development, immune responses, and the development of more effective therapeutics. Ultimately, this review explores the dual role of IκB kinases in cancer, focusing on the impact of phosphorylation events and crosstalk with other signaling pathways, shedding light on their intricate regulation and multifaceted functions in both inflammation and cancer.

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Section: Non-canonical Nf-κb Pathwaymentioning

confidence: 99%

The Yin and Yang of IκB Kinases in Cancer

Abdrabou

2023

Kinases and Phosphatases

View full text Add to dashboard Cite

show abstract

NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis

Cited by 1 publication

References 68 publications

The Yin and Yang of IκB Kinases in Cancer

The Yin and Yang of IκB Kinases in Cancer

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