NF-κB in Anti-Inflammatory Activity of Probiotics: An Update

Rodríguez, Ana V.; Griet, Milagros

doi:10.2174/1573395512666160108000446

Cited by 5 publications

(2 citation statements)

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“…The main molecular targets of the substances present in these probiotics are presumed to be the NF-κB and/or MAPK pathways. Bioactive compounds derived from probiotics emerge as a promising therapeutic strategy for mitigating excessive and/or prolonged inflammatory reactions [ 296 , 297 , 298 ].…”

Section: Antiviral Antibacterial Antioxidants Anticancer and Anti-inf...mentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced by microorganisms that exert biological effects on the hosts”; and (iii) “compounds produced by microorganisms, released from food components or microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health and wellbeing”. A probiotic- and prebiotic-rich diet ensures an adequate supply of these vital nutrients. During the anaerobic fermentation of organic nutrients, such as prebiotics, postbiotics act as a benevolent bioactive molecule matrix. Postbiotics can be used as functional components in the food industry by offering a number of advantages, such as being added to foods that are harmful to probiotic survival. Postbiotic supplements have grown in popularity in the food, cosmetic, and healthcare industries because of their numerous health advantages. Their classification depends on various factors, including the type of microorganism, structural composition, and physiological functions. This review offers a succinct introduction to postbiotics while discussing their salient features and classification, production, purification, characterization, biological functions, and applications in the food industry. Furthermore, their therapeutic mechanisms as antibacterial, antiviral, antioxidant, anticancer, anti-diabetic, and anti-inflammatory agents are elucidated.

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Section: Antiviral Antibacterial Antioxidants Anticancer and Anti-inf...mentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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“…Many probiotics have shown efficacy in alleviating the symptoms of IBD and other inflammatory gastrointestinal diseases. NF-κB and/or MAPK pathways have been proposed to be the key molecular targets of compounds contained in these probiotics [69][70][71][72].…”

Section: Nf-κb and Mapk Pathwaysmentioning

confidence: 99%

Molecular and Cellular Mechanisms Influenced by Postbiotics

Jastrząb

Graczyk

Siedlecki

2021

IJMS

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In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a plethora of functions, including the synthesis of bioactive products, metabolism of dietary compounds, and immunomodulation, both through attenuation and immunostimulation. An imbalance in the microbiota population, i.e., dysbiosis, has been linked to many human pathologies, including various cancer types and neurodegenerative diseases. Targeting gut microbiota and microbiome–host interactions resulting from probiotics, prebiotics, and postbiotics is a growing opportunity for the effective treatment of various diseases. As more research is being conducted, the microbiome field is shifting from simple descriptive analysis of commensal compositions to more molecular, cellular, and functional studies. Insight into these mechanisms is of paramount importance for understanding and modulating the effects that microbiota, probiotics, and their derivatives exert on host health.

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