Biochemical Pharmacology volume 81, issue 3, P412-424 2011 DOI: 10.1016/j.bcp.2010.10.014 View full text
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Alfeu Zanotto-Filho, Elizandra Braganhol, Rafael Schröder, Luís Henrique T. de Souza, Rodrigo J.S. Dalmolin, Matheus A. Bittencourt Pasquali, Daniel Pens Gelain, Ana Maria Oliveira Battastini, José Cláudio Fonseca Moreira

Abstract: Identification of novel target pathways in glioblastoma (GBM) remains critical due to poor prognosis, inefficient therapies and recurrence associated with these tumors. In this work, we evaluated the role of nuclear-factor-kappa-B (NFκB) in the growth of GBM cells, and the potential of NFκB inhibitors as antiglioma agents. NFκB pathway was found overstimulated in GBM cell lines and in tumor specimens compared to normal astrocytes and healthy brain tissues, respectively. Treatment of a panel of established GBM …

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