Next generation NIR fluorophores for tumor imaging and fluorescence-guided surgery: A review

Haque, Ashanul; Faizi, Md. Serajul Haque; Rather, Jahangir Ahmad; Khan, Muhammad S.

doi:10.1016/j.bmc.2017.02.061

Cited by 154 publications

(112 citation statements)

References 147 publications

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“…NIRF dyes, as drug carriers, covalently conjugate to chemotherapeutic agents, facilitating the ability of drugs to penetrate the blood tumor barrier (BTB). It has been reported that NIRG conjugates can penetrate the BBB/BTB to inhibit brain tumors and prostate tumor brain metastases and prolong the survival of mice [10]. In this study, we also demonstrated the exclusive accumulation of the DZ-1 conjugated with gemcitabine (NIRG) in liver tumors of PDX mice, and restricted the growth of HCC effectively (Figure 6).…”

Section: Discussionsupporting

confidence: 65%

“…Twenty days later, mice were injected intraperitoneally with either saline or NIRG (10 mg/kg) twice a week for four weeks [10]. The tumor size was measured at seven, 14, 21, and 28 days after administration of NIRG [20].…”

Section: Resultsmentioning

confidence: 99%

“…An ideal imaging fluorophore probe for clinical application should possess the properties of selective accumulation, intense emission, high photo-stability, and high quantum yields [30]. To meet these challenges, researchers are now focusing on the development of new probes with improved photophysical properties, ability for localization, and stability [10]. …”

Section: Discussionmentioning

confidence: 99%

“…They have shown great potential for both experimental and clinical imaging [5,6], including real-time visualization of certain anatomical structures during surgery [7,8]. Many NIRF agents, such as Cy5.5 and IR800-CW, have been successfully used for diagnosis in tumor models after labeling with an experimental peptide or a specific antigen [9,10]. A representative NIRF agent is indocyanine green (ICG), which is the only FDA-approved NIRF dye for clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

Zhang

Zhao

Zhou

et al. 2017

IJMS

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Near infrared fluorescence (NIRF) imaging has strong potential for widespread use in noninvasive tumor imaging. Indocyanine green (ICG) is the only Food and Drug Administration (FDA) -approved NIRF dye for clinical diagnosis; however, it is unstable and poorly targets tumors. DZ-1 is a novel heptamethine cyanine NIRF dye, suitable for imaging and tumor targeting. Here, we compared the fluorescence intensity and metabolism of DZ-1 and ICG. Additionally, we assayed their specificities and abilities to target tumor cells, using cultured hepatocellular carcinoma (HCC) cell lines, a nude mouse subcutaneous xenograft model of liver cancer, and a rabbit orthotopic transplantation model. We found that DZ-1 accumulates in tumor tissue and specifically recognizes HCC in subcutaneous and orthotopic models. The NIRF intensity of DZ-1 was one order of magnitude stronger than that of ICG, and DZ-1 showed excellent intraoperative tumor targeting in the rabbit model. Importantly, ICG accumulated at tumor sites, as well as in the liver and kidney. Furthermore, DZ-1 analog-gemcitabine conjugate (NIRG) exhibited similar tumor-specific targeting and imaging properties, including inhibition of tumor growth, in HCC patient-derived xenograft (PDX) mice. DZ-1 and NIRG demonstrated superior tumor-targeting specificity, compared to ICG. We show that DZ-1 is an effective molecular probe for specific imaging, targeting, and therapy in HCC.

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Section: Discussionsupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

Zhang

Zhao

Zhou

et al. 2017

IJMS

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“…Recently, near-infrared (NIR) fluorescent probes have received much attention due to its advantages in deep tissue penetration, low background interference and minimal damage to cells and tissues [23–26]. While significant advances have been made towards detecting cellular targets or small molecules with near-IR probes [24–28], no such probes for Pb(II) detection in living cells were reported.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

Fang

Wang

et al. 2017

Inorganica Chimica Acta

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A new near-infrared fluorescent probe (NIR-PbP) for sensitive detection of Pb(II) ions in solution and living cells has been rationally designed and synthesized. The NIR-PbP is inherently non-fluorescent and gains fluorescence in the presence Pb(II) ions. The ion detection is based on Pb(II)-induced unmasking the fluorophore through the opening of the spyrocycle, with more than 500-fold fluorescence for sub-micromolar Pb(II) concentration. The NIR-PbP has high sensitivity, good photo-stability, low detection limit, and reversible response to Pb(II) ions.

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Type‐II CdSe/ZnO Core/Shell Nanorods: Nanoheterostructures with A Tunable Dual Emission in Visible and Near‐Infrared Spectral Ranges

Haque,

Zechel,

Vretenár

et al. 2024

Adv Funct Materials

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A synthesis and characterization of luminescent nano‐heterostructures consisting of CdSe nanorod (NR) cores and a ZnO shell with up to three monolayers of ZnO is reported. The core/shell heterostructures show a tunable, dual photoluminescence (PL) in visible and Near Infrared (NIR) spectral ranges. Upon shelling the visible PL band attributed to the carrier recombination within the CdSe core shifts to lower energy by ≈0.05 to 0.15 eV relative to the bare CdSe NRs, due to a reduced quantum confinement. A NIR band, observed ≈0.4 – 0.5 eV below the PL energy of the CdSe core, is attributed to a type‐II carrier recombination across the CdSe/ZnO interface. The total PL quantum yield (PLQY) in the brightest heterostructures reaches ≈20%, increasing ≈100‐fold over the PLQY of the corresponding bare CdSe NRs. The average lifetimes of the visible PL in some heterostructures exceeds 100 ns, compared to ≈5 ns lifetime typical for bare CdSe NRs. The average PL lifetimes attributed to the type‐II charge separated states exceed one microsecond. Strong NIR PL, tunable in the 800–900 nm spectral range and the long‐lived charge separated state make the CdSe/ZnO core‐shell NRs appealing materials for exploitation in applications such as bioimaging, photocatalysis and optoelectronics.

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Next generation NIR fluorophores for tumor imaging and fluorescence-guided surgery: A review

Cited by 154 publications

References 147 publications

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

Type‐II CdSe/ZnO Core/Shell Nanorods: Nanoheterostructures with A Tunable Dual Emission in Visible and Near‐Infrared Spectral Ranges

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