1998
DOI: 10.1074/jbc.273.6.3649
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Abstract: Ras and Rho are involved in the regulation of signal transduction events governing cell growth and cell proliferation. Protein prenylation is essential for the activation and/or the translocation of these small GTPases; however, protein geranylgeranylation rather than farnesylation is required for G 1 /S transition. We studied prenylation and translocation of Ras and Rho A during

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Cited by 51 publications
(38 citation statements)
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“…This may be due to the fact that after 24 h of treatment, there was no effect of PDGF, GGPP, or FPP on the level of Ras in the cellular membrane. These findings are consistent with recent studies showing that the translocation of Rho, but not Ras, to the membrane corresponds with cell cycle progression from G 1 to S in FRTL-5 cells (33,34) and that GGPP completely reversed the up-regulation of p27…”
Section: Effects Of Rho On Smooth Muscle Cell Cycle Progression-tosupporting
confidence: 82%
“…This may be due to the fact that after 24 h of treatment, there was no effect of PDGF, GGPP, or FPP on the level of Ras in the cellular membrane. These findings are consistent with recent studies showing that the translocation of Rho, but not Ras, to the membrane corresponds with cell cycle progression from G 1 to S in FRTL-5 cells (33,34) and that GGPP completely reversed the up-regulation of p27…”
Section: Effects Of Rho On Smooth Muscle Cell Cycle Progression-tosupporting
confidence: 82%
“…We propose the cytoskeleton signals the nucleus to alter expression of genes important for cell cycle progression. In this regard, Zhu et al (1996) reported that in order for cell cycle progression to occur, the actin cytoskeleton must be assembled, and Noguchi et al (1998) recently reported that activation of RhoA and not Ras is necessary for G1 to S transition in rat thyroid cells. Our results imply that it is the activation of RhoA with the development of actin stress ®bers and intracellular tension that signals cell cycle progression.…”
Section: Discussionmentioning
confidence: 99%
“…5A and B, arrows; ref. 30). The distribution of GTPases at the plasma membrane dissipated after 15 minutes, and within 30 minutes of release, Ras and RhoA resided predominantly in the cytoplasm.…”
Section: Resultsmentioning
confidence: 99%