Newborn screening program for congenital hypothyroidism in Montenegro

Samardžić, Mira; Gligorovic-Barhanovic, Najdana; Popović, Nataša; Popović-Samardžić, Milena

doi:10.5457/p2005-114.70

Cited by 5 publications

(3 citation statements)

References 15 publications

(12 reference statements)

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“…Between 2002 and 2015, overall CH incidence confirmed at birth was 1/1976. This is higher than the incidence of primary CH reported for neighboring Serbia (1:3728) [15], and some of the other countries in the region, such as Montenegro (1/2397) [16], Slovenia (1/2323) [17], and Croatia (1/4127) [18]. There were variations in the CH incidence among different regions of the country.…”

Section: Discussioncontrasting

confidence: 42%

Regional Variation in the Incidence of Congenital Hypothyroidism in Macedonia

Anastasovska

Sukarova-Angelovska²,

Pesevska

et al. 2017

IJNS

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Abstract:The incidence of congenital hypothyroidism (CH) is increasing in different areas around the world. Potential causes include changes in population ethnic composition, environmental factors, changing screening program methodology and lowering of TSH cutoff levels. The incidence of CH in different regions of Macedonia has not been evaluated before. A total of 251,008 newborns from all eight regions in the country have been screened between 2002 and 2015, by measurement of the thyroid-stimulating hormone (TSH) from blood spots, sampled 48-72 h after birth, using the DELFIA assay. Overall CH incidence confirmed at birth was 1/1976. The highest CH incidence was observed in the Vardar region (1/970), while the Eastern region had the lowest incidence (1/4202; p = 0.021). In the other regions, the following CH incidence was detected: Northeastern 1

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Section: Discussioncontrasting

confidence: 42%

Regional Variation in the Incidence of Congenital Hypothyroidism in Macedonia

Anastasovska

Sukarova-Angelovska²,

Pesevska

et al. 2017

IJNS

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“…It is two-times higher than the state average 1:2602 [ 2 ] and three-times higher than estimated in the capital city, 1:3389 (unpublished results), for the same period. The incidence of CH is also significantly higher in this region compared with surrounding countries [ 3 , 4 ] and developing countries, in general (from 1:3000 to 1:4000), [ 5 ]. However, a high incidence of CH was reported in The Netherlands 1:1300 [ 6 ], Thailand 1:1800 [ 7 ] and Lebanon 1:1823 [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Congenital Hypothyroidism in One Region of the Republic of Macedonia

Anastasovska

Koviloska²,

Kočova

2014

Balkan Journal of Medical Genetics

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Congenital hypothyroidism (CH) is the most common preventable cause of mental retardation in children. Diagnosis is difficult at birth without neonatal screening. Neonatal thyroid screening was established in Prilep, Republic of Macedonia as an integral part of the nationwide screening program. To estimate the prevalence of CH in this region, neonatal thyroid screening was performed on 9757 newborns, during the period 2002–2011. The DELFIA method was applied to measure the thyroid-stimulating hormone (TSH) concentration in dried blood spot samples on standard filter paper taken 48 hours after birth by heel-stick. The TSH cut-off level was 10 mU/L.The neonatal thyroid screening coverage was 93.4%. Eight newborns with CH were detected, with an incidence of 1:1220 live births, significantly higher compared to the nationwide results 1:2602. The TSH level was not significantly dependent on the gender of the newborn. There was a statistically significant difference between the TSH level and the timing of newborn screening sampling (p <0.05) and between the TSH level and the newborn birth weight (p = 0.01). One point ninety-two percent of newborns with TSH levels above 5 mU/L indicated an iodine sufficiency in Prilep. The incidence of CH in Prilep, which is higher when compared with that reported in surrounding countries, might be a consequence of the higher percentage of the Romany population in this region. Further analysis of this population in other regions is warranted.

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“…The results showed even greater heterogeneity of the NBS in the region than before, considering that Croatia and Slovenia managed to expand the NBS by the use of MS/MS with high coverage (percentage of newborns included), while the basics -for example PKU screening remained suboptimally implemented in the region, as some of the countries (Montenegro) still did not have a mandatory screening for it (10)(11)(12). On the other hand, mandatory screening for CH was successfully implemented in North Macedonia, Montenegro and Romania, where the national registry for CH (MEDILOG) was established in the same year (13)(14)(15). The circumstances in Kosovo were worrying, as the NBS was non-existent.…”

Section: Discussionmentioning

confidence: 99%

Current Status of Newborn Screening in Southeastern Europe

et al. 2021

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Significant part of Southeastern Europe (with a population of 76 million) has newborn screening (NBS) programs non-harmonized with developed European countries. Initial survey was conducted in 2013/2014 among 11 countries from the region (Albania, Bulgaria, Bosnia and Herzegovina (BIH), Croatia, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, and Slovenia) to assess the main characteristics of their NBS programs and their future plans. Their cumulative population at that time was ~52,5 million. At that time, none of the countries had an expanded NBS program, while phenylketonuria screening was not introduced in four and congenital hypothyroidism in three of 11 countries. We repeated the survey in 2020 inviting the same 11 countries, adding Cyprus, Greece, Hungary, and Malta (due to their geographical position in the wider region). The aims were to assess the current state, to evaluate the change in the period, and to identify the main obstacles impacting the implementation of expanded NBS and/or reaching a wider population. Responses were collected from 12 countries (BIH—Federation of BIH, BIH—Republic of Srpska, Bulgaria, Croatia, Greece, Hungary, Kosovo, North Macedonia, Malta, Montenegro, Romania, Serbia, Slovenia) with a population of 68.5 million. The results of the survey showed that the regional situation regarding NBS only modestly improved in this period. All of the surveyed countries except Kosovo screened for at least congenital hypothyroidism, while phenylketonuria was not screened in four of 12 countries. Croatia and Slovenia implemented an expanded NBS program using tandem mass spectrometry from the time of last survey. In conclusion, the current status of NBS programs in Southeastern Europe is very variable and is still underdeveloped (or even non-existent) in some of the countries. We suggest establishing an international task-force to assist with implementation and harmonization of basic NBS services where needed.

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Newborn screening program for congenital hypothyroidism in Montenegro

Cited by 5 publications

References 15 publications

Regional Variation in the Incidence of Congenital Hypothyroidism in Macedonia

Regional Variation in the Incidence of Congenital Hypothyroidism in Macedonia

High Incidence of Congenital Hypothyroidism in One Region of the Republic of Macedonia

Current Status of Newborn Screening in Southeastern Europe

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