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Cited by 16 publications
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“…Tetrahydrocarbazole 3 was obtained by acid cyclization following two previously reported methods: method A, consisting of cyclization by H 2 SO 4 (4 %), and method B, by ion-exchange resin, Amberlyst in aprotic media (toluene). [40] Both methods were quite advantageous (respective yields of 48 and 64 %). The same compound 3 was also directly obtained from the starting hydrazine hydrochloride derivative and cyclohexanone in glacial acetic acid by a one-pot microwave-assisted reaction in high yield (80 %), as previously reported.…”
Section: Chemistrymentioning
confidence: 98%
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“…Tetrahydrocarbazole 3 was obtained by acid cyclization following two previously reported methods: method A, consisting of cyclization by H 2 SO 4 (4 %), and method B, by ion-exchange resin, Amberlyst in aprotic media (toluene). [40] Both methods were quite advantageous (respective yields of 48 and 64 %). The same compound 3 was also directly obtained from the starting hydrazine hydrochloride derivative and cyclohexanone in glacial acetic acid by a one-pot microwave-assisted reaction in high yield (80 %), as previously reported.…”
Section: Chemistrymentioning
confidence: 98%
“…The latter, upon treatment with chloroethyldiethylenamine hydrochloride in DMF and K 2 CO 3 , yielded 28, in which the side chain is at the 6-position as shown by 1 H and 13 C NMR and IR data, and by comparison with data obtained for the corresponding tetrahydrogenated compound 13 (Scheme 2). Finally, in order to complete the series of PQ derivatives previously obtained, [40] we synthesized the pyrroloA C H T U N G T R E N N U N G [3,2-f]-A C H T U N G T R E N N U N G quinoline analogues of 13 and 28 with one side chain at position 4, as shown in Scheme 5. Compound 29, obtained by a previously reported procedure, [40] was demethoxylated with 48 % HBr and simultaneously decarboxylated to the 4-hydroxy derivative 30.…”
Section: Chemistrymentioning
confidence: 99%
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“…They are used as antibacterial, 1,2 antimalarial, [1][2][3][4] antileishmanial, 4 antituberculosis, 5 antiplatelet, 6 antidepressant, 7 antipsychotic, 8 antiinflammatory, 9 antirheumatic, 10 antiulcer, 11 anticonvulsant, 9,12 cardiac stimulant, 13 andanticanceragents. [14][15][16] The quinoline chromophore represents the basis for the pre-clinical and clinical development of novel antimalarial, antipsychotic, and antitumor agents. Some of these agents are in use as potent drugs (imidazoquinoline, hydrochloroquine, aripiprazole).…”
Section: Introductionmentioning
confidence: 99%