New water‐soluble photo crosslinkable polymers based on modified poly(vinyl alcohol)

Abstract

Poly(vinyl alcohol) (PVA) was partially modified by polymer analogous reaction with acrylic and methacrylic acid and with 2-vinyl-4,4-dimethyl-azlactone to obtain water-soluble polymers with pendant (meth)acrylate and acrylamide groups. Aqueous solutions of these polymers were crosslinked by UV-irradiation within seconds to form transparent networks with potential for use in contact lenses. The water content of these hydrogels was studied as a function of polymer molecular weight, the acetate, (meth)acrylate, and methacrylamide contents and irradiation conditions. The hydrogels showed good mechanical properties, even at low crosslinker ( õ5 mol %) and high water contents (60-80%). The formation kinetics and stability of aggregates, investigated by combined GPC/light-scattering measurements of samples annealed and/or stored at different temperatures ( 020 to 100ЊC), give insight into PVA secondary structures.

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

“…The scope and utility of direct covalent coupling of PVA with candidate drug and/or polymer chains for advanced macromolecular engineering is rather limited and modification of hydroxyls is largely considered to introduce more convenient sites for conjugation, chain extension, and/or substrate immobilization. Examples of the latter include (meth)acrylates,36–39 thiol groups,40–43 carboxylic groups,44–46 halides,47 and fatty acids 48, 49. In these applications, esters are among the most popular linkages employed,50–52 and their formation typically relies on PVA reaction with carboxylic acids, acid chlorides,47 or anhydrides 44, 45.…”

A New Approach for in vitro Imaging of Breast Cancer Cells by Anti‐Metadherin Targeted PVA‐Pyrene

“…Several research groups have investigated the addition of methacrylate and acrylate pendant groups to the PVA macromer. Specifically, acrylic and methacrylic acid, [18] glycidyl acrylate, [19] glycidyl methacrylate [20,21] and 2-isocyanatoethyl methacrylate [22] have all been used to functionalize the PVA backbone.…”

Photosensitive injectable systems for biomedical applications

“…Pierwsze próby modyfikacji fotosieciowalnego PVA dotyczy³y materia³ów na soczewki kontaktowe i polega-³y na prostym przy³¹czeniu, bezpooerednio do wolnych grup hydroksylowych, reszt kwasu akrylowego i metakrylowego [31]. Znana jest te¿ inna metoda modyfikacji na drodze reakcji PVA z zawieraj¹cym wi¹zanie izocyjanianowe metakrylanem 2-izocyjanianoetylu [7].…”