New Total Ossicular Replacement Prostheses With a Resilient Joint

Arechvo, Irina; Bornitz, Matthias; Lasurashvili, Nikoloz; Zahnert, Thomas; Beleites, Thomas

doi:10.1097/mao.0b013e31823c9352

Cited by 17 publications

(19 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, columella-like prostheses either with a micro ball joint or a resilient joint were developed with the aim to allow prostheses to adapt to large but slow tympanic membrane displacements [8,9]. However, the length variability of these prostheses is limited [8]. Nevertheless, an important finding of experimental and clinical studies with these prostheses is that a joint within the prosthesis allows absorption of some of the non-acoustic forces without disturbing the sound transfer [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Tympanic membrane retraction due to Eustachian tube dysfunction may result in tilting of the prosthesis, prosthesis migration and extrusion, or a dislocation of the prosthesis into the vestibulum. Recently, columella-like prostheses either with a micro ball joint or a resilient joint were developed with the aim to allow prostheses to adapt to large but slow tympanic membrane displacements [8,9]. However, the length variability of these prostheses is limited [8].…”

Section: Introductionmentioning

confidence: 99%

“…However, the length variability of these prostheses is limited [8]. Nevertheless, an important finding of experimental and clinical studies with these prostheses is that a joint within the prosthesis allows absorption of some of the non-acoustic forces without disturbing the sound transfer [8,9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parameters for novel incus replacement prostheses

Kaftan

Böhme

Martin

2015

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Prostheses replacing the incus in its normal position and equipped with two joints might transfer sound as effectively as the intact ossicular chain and allow adjustment to quasi-static pressure changes. A prerequisite for prostheses development is the access to dimensions and distances of the ossicular chain which are necessary to conceptualize shape and size. Fifteen cadaveric human temporal bone specimens were investigated by means of micro-CT followed by 3D analysis. Each specimen was scanned three times: after removal of incus, after additional removal of the malleus head, and after approaching the umbo to the promontory. Artificial umbo medialization as a surrogate for quasi-static pressure changes leads to relevant variations in the distance between the upper part of the malleus and the stapes. Prostheses replacing the incus in its normal position should be equipped with a sliding ball joint or similar construction to allow adjustment to quasi-static pressure changes.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parameters for novel incus replacement prostheses

Kaftan

Böhme

Martin

2015

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…155 Comparative anatomy has informed ossicular replacement prosthesis design, although most attention to date has been focussed on birds. 143,154 A closer look at some of the universal features of tympanic ears among vertebrates in general, such as the apparent requirement for a flexible lever, may provide important insights. 156 Given the diversity of ear types both between and within major vertebrate groups, the species chosen as experimental models for human ear pathologies must be selected with care.…”

Section: Flexibility and Pressure-bufferingmentioning

confidence: 99%

“…149 Attempts to produce such prostheses have met with varying success. [149][150][151][152][153][154] Whether the potential benefits would outweigh the loss of transmission introduced by the additional flexibility has been questioned. 155 Comparative anatomy has informed ossicular replacement prosthesis design, although most attention to date has been focussed on birds.…”

Section: Flexibility and Pressure-bufferingmentioning

confidence: 99%

Flexibility within the middle ears of vertebrates

Mason

Farr

2012

J. Laryngol. Otol.

View full text Add to dashboard Cite

Introduction and aims: Tympanic middle ears have evolved multiple times independently among vertebrates, and share common features. We review flexibility within tympanic middle ears and consider its physiological and clinical implications.Comparative anatomy: The chain of conducting elements is flexible: even the 'single ossicle' ears of most nonmammalian tetrapods are functionally 'double ossicle' ears due to mobile articulations between the stapes and extrastapes; there may also be bending within individual elements.Simple models: Simple models suggest that flexibility will generally reduce the transmission of sound energy through the middle ear, although in certain theoretical situations flexibility within or between conducting elements might improve transmission. The most obvious role of middle-ear flexibility is to protect the inner ear from high-amplitude displacements.Clinical implications: Inter-ossicular joint dysfunction is associated with a number of pathologies in humans. We examine attempts to improve prosthesis design by incorporating flexible components.

show abstract

Biomimetic Tympanic Membrane Replacement Made by Melt Electrowriting

Witzleben

Stoppe

Ahlfeld

et al. 2021

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

The tympanic membrane (TM) transfers sound waves from the air into mechanical motion for the ossicular chain. This requires a high sensitivity to small dynamic pressure changes and resistance to large quasi-static pressure differences. The TM achieves this by providing a layered structure of about 100µm in thickness, a low flexural stiffness, and a high tensile strength. Chronically infected middle ears require reconstruction of a large area of the TM. However, current clinical treatment can cause a reduction in hearing. With the novel additive manufacturing technique of melt electrowriting (MEW), it is for the first time possible to fabricate highly organized and biodegradable membranes within the dimensions of the TM. Scaffold designs of various fiber composition are analyzed mechanically and acoustically. It can be demonstrated that by customizing fiber orientation, fiber diameter, and number of layers the desired properties of the TM can be met. An applied thin collagen layer seals the micropores of the MEW-printed membrane while keeping the favorable mechanical and acoustical characteristics. The determined properties are beneficial for implantation, closely match those of the human TM, and support the growth of a neo-epithelial layer. This proves the possibilities to create a biomimimetic TM replacement using MEW. IntroductionDefects of the tympanic membrane (TM) have many causes, ranging from injuries to chronic otitis media (COM). In the

show abstract

New Total Ossicular Replacement Prostheses With a Resilient Joint

Cited by 17 publications

References 15 publications

Parameters for novel incus replacement prostheses

Parameters for novel incus replacement prostheses

Flexibility within the middle ears of vertebrates

Biomimetic Tympanic Membrane Replacement Made by Melt Electrowriting

Contact Info

Product

Resources

About