New Therapeutics in Hypertension

Improvement of the antihypertensive capacity of candesartan and trityl candesartan by their SOD mimetic copper(II) complexes

“…The UV-vis spectrum of [1] (670 nm, ethanolic solution, pH 8.4) was different from the diffuse reflectance spectrum measured for the solid compound, indicating a probable replacement of the coordinated water molecules by ethanol. The formation of [1] was followed spectrophotometrically at the pH value used in its synthesis. The visible spectra of ethanolic 1:1 solutions of candesartan and copper(II) (0.025 M) at different pH values were measured (Fig.…”

“…[Cu(Cand)(H 2 O) 4 ] (CuCand) [1]: A solution of CuCl 2 •2H 2 O in ethanol (1 mmol, 5 mL) was added under continuous stirring to an ethanolic solution of candesartan (1 mmol, 10 mL). The solution was allowed to stir at 60 °C and an aqueous solution of 1 M NaOH was added up to pH 7-8.…”

“…According to Hathaway [29] a G value less than four indicates a considerable exchange interaction in the solid complexes, while a higher value indicates that the magnetic interaction is negligible. In complex [1], G is 4.64 which indicates the occurrence of no interaction between the copper centers.…”

“…On the other hand, the stability of the complex was assessed following the changes of the electronic spectral band of [1] as a function of time (ethanolic solution, 5 × 10 −3 M). Since the absorbance of the solution was reduced ca.…”

“…Sartans are synthetic substances that have the renin-angiotensin system (RAS) as the target of their mechanism of action. They inhibit the angiotensin converting enzyme (ACE) which is mainly responsible for the conversion of angiotensin I into angiotensin II (that induces a direct vasoconstrictor action causing hypertension) [1].…”