2019
DOI: 10.1101/799031
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Abstract: Aging causes epigenetic modifications, which are utilized as a biomarker for the aging process.While genome-wide DNA methylation profiles enable robust age-predictors by integration of many age-associated CG dinucleotides (CpGs), there are various alternative approaches for targeted measurements at specific CpGs that better support standardized and cost-effective highthroughput analysis. In this study, we utilized 4,650 Illumina BeadChip datasets of blood to select the best suited CpG sites for targeted analys… Show more

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Cited by 8 publications
(20 citation statements)
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“…In addition, CTCF could collaborate with Cockayne syndrome group B protein (CSB) to protect cells from oxidative stress and therefore delay aging ( Lake et al, 2016 ). CTCF could also bind with the human longevity gene forkhead box O3 (FOXO3) and bind close to the peak of age-associated DNA changes and thereby participate in aging progression ( Badarinarayan et al, 2017 ; Flachsbart et al, 2017 ; Han et al, 2020 ). In the present study, we successfully showed that CTCF, when binding to the POLD1 promoter, regulates the aging process.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, CTCF could collaborate with Cockayne syndrome group B protein (CSB) to protect cells from oxidative stress and therefore delay aging ( Lake et al, 2016 ). CTCF could also bind with the human longevity gene forkhead box O3 (FOXO3) and bind close to the peak of age-associated DNA changes and thereby participate in aging progression ( Badarinarayan et al, 2017 ; Flachsbart et al, 2017 ; Han et al, 2020 ). In the present study, we successfully showed that CTCF, when binding to the POLD1 promoter, regulates the aging process.…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, we tested these and additional COVID-19 samples with a targeted bisulfite amplicon sequencing (BA-seq) of age-associated regions. We have recently described BA-seq for nine CpGs that provide robust and reliable age predictions (Han et al, 2020).…”
Section: Introduction Results and Discussionmentioning
confidence: 99%
“…To further ease applicability of the method we have meanwhile refined the signature to Phosphodiesterase 4C (PDE4C), as described before (Han et al, 2020). We utilized BA-seq data of 40 healthy blood samples of our previous work to derive the following multivariable model: Epigenetic age (years) = -0.34 DNAm CCDC102B + 0.83 DNAm FHL2 + 1.18 DNAm PDE4C + 3.86…”
Section: Introduction Results and Discussionmentioning
confidence: 99%
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