New Steroid Acids from Antrodia cinnamomea, a Fungal Parasite of Cinnamomum micranthum

Chen, Chung Hsiung; Yang, Shaoxiang; Shen, Ya Ching

doi:10.1021/np50125a002

Cited by 135 publications

(124 citation statements)

References 6 publications

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“…Antrodia cinnamomea, an endemic mushroom in Taiwan, is a host-specific saprophytic fungus that causes brown rot in C. kanehirae. The fruiting bodies and mycelia of A. cinnamomea contain substances with anticancer, antiinflammatory, anticholinergic, blood pressure regulatory and antiserotonergic activities (Chen et al 1995;Shen et al 2003;Chang and Wang 2005).…”

Section: Introductionmentioning

confidence: 99%

Tracking the geographical origin of timber by DNA fingerprinting: a study of the endangered species Cinnamomum kanehirae in Taiwan

Hung

Lin

2017

Holzforschung

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Cinnamomum kanehirae Hay. is endemic in Taiwan and is severely threatened due to intensive utilization and illegal logging. To combat illegal logging, suitable identification markers are needed, which are usable in a court of law, such as microsatellite marker for genotyping. In the present paper, a genetic fingerprinting database was generated based on 15 microsatellites, which are suitable to assess the timber's origin and its population genetic structure. The quality of DNA extractions from C. kanehirae timbers was assessed by comparing cpDNA trnL-trnF sequence lengths. The cumulative probability of identifying unrelated individuals in these microsatellites was 5.151 × 10 −17. The results indicate that the low genetic diversity is a consequence of illegal logging and that there is a significant genetic differentiation among C. kanehirae populations. It was possible to trace back the geographical origin of unknown C. kanehirae timbers based on a genetic reference database, i.e. all blind wood samples were assigned to their true geographical origins. Accordingly, microsatellites are a useful tool to identify the population origins of timbers and can be considered as a tool for combating illegal logging of C. kanehirae.

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Section: Introductionmentioning

confidence: 99%

Tracking the geographical origin of timber by DNA fingerprinting: a study of the endangered species Cinnamomum kanehirae in Taiwan

Hung

Lin

2017

Holzforschung

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“…A triterpenoid sesquiterpene lactone, steroid, and polysaccharides are the bioactive ingredients in T. camphoratus. [19][20][21][22] However, more unknown ingredients remain to be discovered and identified. Two types of artificial cultivation of T. camphoratus, a solid-state culture and liquid-state fermentation, were developed to substitute for the rare wild fruiting body.…”

mentioning

confidence: 99%

Taiwanofungus camphoratusActivates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats

Suk

Lin

Chen

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…The five antcins were separately purified as a mixture of two C-25 epimers, and the correctness of these compounds was confirmed by comparing their spectral data of NMR and Mass (data not shown) with those of antcins described in the literatures [13,21,32] .…”

Section: Resultsmentioning

confidence: 98%

“…Fraction 9E was subjected to semipreparative HPLC eluted with CH 2 Cl 2 -i-propanol (9:1) to yield antcin K (4.1 mg). The five purified antcins in a mixture of two epimers at C-25 were confirmed by their spectra of 1 H-NMR, 13 C-NMR and HR-EI-MS n .…”

Section: Preparation Of Antcinsmentioning

confidence: 85%

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Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids

Chen¹,

Liu

et al. 2011

Acta Pharmacol Sin

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Aim: To determine the active ingredient of Niuchangchih (Antrodia camphorata) responsible for its anti-inflammatory effects and the relevant molecular mechanisms. Methods: Five major antcins (A, B, C, H, and K) were isolated from fruiting bodies of Niuchangchih. Structural similarity between the antcins and 2 glucocorticoids (cortisone and dexamethasone) was compared. After incubation with each compound, the cytosolic glucocorticoid receptor (GR) was examined for its migration into the nucleus. Mo lecular docking was performed to model the tertiary structure of GR associated with antcins. Results: Incubation with cortisone, dexamethasone or antcin A (but not antcins B, C, H, and K) led to the migration of glucocorticoid receptor into the nucleus. The minimal concentration of antcin A, cortisone and dexamethasone to induce nuclear migration of glucocorticoid receptor was 10, 1, and 0.1 mol/L, respectively. The results are in agreement with the simulated binding affinity scores of these three ligands docking to the glucocorticoid receptor. Molecular modeling indicates that C-7 of antcin A or glucocorticoids is exposed to a hydrophobic region in the binding cavity of the glucocorticoid receptor, and the attachment of a hydrophilic group to C-7 of the other four antcins presumably results in their being expelled when docking to the cavity. Conclusion: The anti-inflammatory effect of Niuchangchih is, at least, partly attributed to antcin A that mimics glucocorticoids and triggers translocation of glucocorticoid receptor into nucleus to initiate the suppressing inflammation.

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New Steroid Acids from Antrodia cinnamomea, a Fungal Parasite of Cinnamomum micranthum

Cited by 135 publications

References 6 publications

Tracking the geographical origin of timber by DNA fingerprinting: a study of the endangered species Cinnamomum kanehirae in Taiwan

Tracking the geographical origin of timber by DNA fingerprinting: a study of the endangered species Cinnamomum kanehirae in Taiwan

Taiwanofungus camphoratusActivates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats

Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids

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