New spectrophotometric method for the determination of some drugs with iodine and wool fast blue BL

Sastry, C. S. P.; Rao, S.Gopala; Naidu, P. Y.; Srinivas, K

doi:10.1016/s0039-9140(97)00237-3

Cited by 34 publications

(17 citation statements)

References 8 publications

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“…The spectrophotometric determination of AMP, PEN-V, AMO and CLO in pharmaceutical formulations was based on their reactivity with an excess of iodine in the presence of NaOH and the unreacted iodine was determined by the measurement of the decrease in the absorbance of the dye wool fast blue BL (k max = 540 nm) [120].…”

Section: Nonchromatographic Techniquesmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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Natural penicillin (benzylpenicillin) is the oldest antibiotic observed by Alexander Fleming in 1928. To broaden its spectrum of activity, natural penicillin was modified, giving rise to a group of antibiotics under the name 'penicillins'. Although an increasing number of bacteria appear to be resistant to them, penicillins are used to treat a variety of bacterial infections including Gram-positive, Gram-negative aerobic and anaerobic bacteria. Consequently, they are widely used in human and veterinary medicine to prevent and treat diseases. This review covers the analytical methodologies, mainly chromatographic, employed to the penicillins determination in pharmaceutical formulations, biological fluids and in production-scale fermentations reported in the literature. Results of published assays are comparatively presented focusing on sample preparation regarding isolation and purification, chromatographic conditions and method validation. Information on chemical structure, spectrum of activity and action mechanism of common penicillins has also been given.

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Section: Nonchromatographic Techniquesmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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“…I have included all those that I could … the names I could pronounce and spell." 55 Stories of these barriers to entry in more desirable specialties were echoed by almost all our interviewees. Perversely, as we have shown, the marginalization of geriatric medicine meant that promotion up the ladder became possible, even if it meant that hopes for success in other specialties such as cardiology or surgery had to be given up.…”

Section: Why Do You Think There's So Many South Asian Doctors Went Inmentioning

confidence: 88%

8. “Without racism there would be no geriatrics”: South Asian Overseas-Trained Doctors and the Development of Geriatric Medicine in the United Kingdom, 1950–2000

Raghuram¹,

Bornat²,

Henry³

2016

Doctors Beyond Borders

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“…Most of the reported methods involve the cleavage of the β-lactam moiety of the cephalosporin structure. These methods include spectrophotometric [2][3][4][5][6] spectrofluorimetric [7][8][9][10]. and electrochemical methods [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Kinetic spectrophotometric determination of certain cephalosporins using iodate/iodide mixture

El-Shaboury

Mohamed²,

Saleh³

et al. 2010

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A simple, precise and accurate kinetic spectrophotometric method for determination of cefradine anhydrous, cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous and cefixime in bulk and in pharmaceutical formulations has been developed. The method based on a kinetic investigation of the reaction of the free carboxylic acid group of the drug with a mixture of potassium iodate and potassium iodide at room temperature to form yellow coloured triiodide ions. The reaction was followed up spectrophotometrically by measuring the increase in absorbance at 352 nm as a function of time. The initial rate, fixed time, variable time and rate-constant methods were adopted for constructing the calibration curves but fixed time method has been found to be more applicable. The analytical performance of the method, in terms of accuracy and precision, was statistically validated; the results were satisfactory. The method has been successfully applied to the determination of the studied drugs in commercial pharmaceutical formulations. Statistical comparison of the results with a well established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision.

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New spectrophotometric method for the determination of some drugs with iodine and wool fast blue BL

Cited by 34 publications

References 8 publications

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

8. “Without racism there would be no geriatrics”: South Asian Overseas-Trained Doctors and the Development of Geriatric Medicine in the United Kingdom, 1950–2000

Kinetic spectrophotometric determination of certain cephalosporins using iodate/iodide mixture

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