New phytoconstituents, anti-microbial and cytotoxic activities of Acacia etbaica Schweinf

Abstract

Acacia etbaica is wild plant growing in the desert of Egypt, and it has folkloric medicinal uses. Phytochemical investigation of Acacia etbaica extracts led to the isolation and identification of seven compounds. Among these compounds are three new simple phenolics: Resacetophenone-6-methyl [1], Resorcinol [2], Resorcinol-O-β -Glucoside [3]; phenolic ester; and other four known compounds: Methylparaben [4]; two chromones, Noreugenin [5], Eugenin [6]; and one cyclitol: pinitol [7]. Compounds [1-3] isolated and identified for the first time from natural origin. In contrast, compounds [4-6] isolated for the first time from the family Fabaceae. The biological investigation was conducted on plant extracts and showed that the methylene chloride extract had a strong efficacy against Bacillus subtilis and good activity against Candida albicans. In contrast, the n-butanol extract showed extreme cytotoxic activity against Mammary gland breast cancer (MCF-7), and strong activity against Hepatocellular carcinoma (HEPG-2), and Colorectal carcinoma (HCT-116) cell lines.

Isolation, structural characterization and evaluation of the in vitro antioxidant potential of four compounds isolated from the selective leaf extracts of Bauhinia monandra Kurz (Fabaceae)

“…The compound ( 4) is D-pinnitol (yellow amorphous solid). NMR ( 1 H, 13 C(APT)) (400 MHz, (CD 3 OD) Spectral data in Table 3 are consistent with those reported in the literature [36][37] .…”

New Specific α‐Glucosidase Inhibitor Flavonoid from Thymelaea tartonraira Leaves: Structure Elucidation, Biological and Molecular Docking Studies

“…The UV absorption bands at 213, 270, 349 nm suggested that compound 4 is a flavone derivative [8] . The 1 H‐NMR spectrum obtained at 400 MHz in (D 6 )DMSO displayed a singlet at δ H 12.80 ppm (1H, s, 5‐OH) attributed to a hydroxy group presenting an intramolecular hydrogen‐band with the carbonyl group [9] . It shows also three signals at δ H 7.53 ppm (1H,d, J =2.4 Hz), δ H 6.88 ppm (1H,d, J =8.4 Hz) and δ H 7.67 ppm (1H,dd, J =8.4 Hz, 2.4 Hz) corresponding to one 1,3,4 tri‐substituted aromatic ring as well as one singlet attributed to an olefinic proton at δ H 6.70 ppm (1H, s).…”

“…[8] The 1 H-NMR spectrum obtained at 400 MHz in (D 6 )DMSO displayed a singlet at δ H 12.80 ppm (1H, s, 5-OH) attributed to a hydroxy group presenting an intramolecular hydrogen-band with the carbonyl group. [9] It shows also three signals at δ H 7.53 ppm (1H,d, J = 2.4 Hz), δ H 6.88 ppm (1H,d, J = 8.4 Hz) and δ H 7.67 ppm (1H,dd, J = 8.4 Hz, 2.4 Hz) corresponding to one 1,3,4 tri-substituted aromatic ring as well as one singlet attributed to an olefinic proton at δ H 6.70 ppm (1H, s). In addition, the presence of an isolated aromatic proton at δ H 6.28 ppm (1H, s) indicated a pentasubstituted aromatic ring.…”

The First Comprehensive Chemical Profiling of Vachellia gummifera (Willd.) Kyal. & Boatwr., a Plant with Medicinal Value

“…Quantification of the compound in both crude extracts by qNMR revealed that it was significantly more abundant in the leaves with 64.83±0.88 mg g −1 DW compared to the stems where 24.89±0.06 mg g −1 DW was observed (Figure 4). Pinitol has previously been identified in Vachellia species including V. nilotica , [13] V. farnesiana , [14] and V. etbaica Schweinf [15] . as well as several Acacia species [9–10] .…”

“…Pinitol has previously been identified in Vachellia species including V. nilotica, [13] V. farnesiana, [14] and V. etbaica Schweinf. [15] as well as several Acacia species. [9][10] In addition to various pharmacological effects including hepatoprotective, anticancer, cardioprotective and anti-inflammatory effects, several studies have reported the anti-diabetic properties of the compound.…”