New Particle Design and Its Preparation of NFkB Decoy Oligodeoxynucleotide (NDON) Loaded PLGA Nanospheres for Gene Delivery

Tsujimoto, Hiroyuki; Tsukada, Yusuke; Hara, Kaori; Kawashima, Yasunaru

doi:10.4164/sptj.44.453

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Bare nanoparticles were redispersed in purified water, and the suspension was mixed with equivalent amounts of 0.05 w/v CS solution. Then, CS-coated nanoparticles were obtained 19,20 .…”

Section: Preparation Of O-carborane-loaded Plga Nanopar-mentioning

confidence: 99%

Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

2019

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Introduction Studies on boron neutron capture therapy BNCT have recently begun garnering attention. It is a cancer treatment method that exploits the nuclear reaction between boron and thermal neutrons, and is based on nuclear capture and fission reactions. Naturally occurring elemental boron has the following two stable isotopes: boron-10 10 B and boron-11 11 B. When 10 B is irradiated with low-energy thermal neutrons, it yields high linear energy transfer LET , α particles 4 He , and recoiling lithium-7 7 Li nuclei. The destructive effects of these high-energy particles are limited to boron-containing cells since the path length of high LET particles in tissue is limited 5-9 µm. Therefore, BNCT can theoretically kill tumor cells without affecting adjacent healthy cells if 10 B atoms can be selectively delivered and accumulated in the interstitial space of

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“…Bare nanoparticles were redispersed in purified water, and the suspension was mixed with equivalent amounts of 0.05 w/v CS solution. Then, CS-coated nanoparticles were obtained 19,20 .…”

Section: Preparation Of O-carborane-loaded Plga Nanopar-mentioning

confidence: 99%

Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

2019

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“…At this time, the external PVA phase is adsorbed onto the surface of the emulsion droplets and prevents the coalescence of emulsion droplets. This principle makes this method suitable for the production of ~200-nm-sized drug-loaded PLGA nanospheres, with a uniform particle size distribution, and it has been researched extensively as a new drug delivery system (DDS) technology (Kimura et al, 2008;Nakano et al, 2009;Hara et al, 2008;Tsujimoto et al, 2007a;2007b).…”

Section: Introductionmentioning

confidence: 99%

“…In this study, the ESD method was scaled (crystallizer size, 100 L) at the Pharmaceutical/Beauty Science Research Center of the Hosokawa Micron Corporation. The following steps were completed: (1) mass production of PLGA nanospheres loaded with useful ingredients for cosmetics and quasi-drugs (Charlesworth et al, 1960), and manufacturing and sale of unique skincare products and hair growth formulas containing these PLGA nanospheres; (2) development of a Good Manufacturing Practice (GMP) production method (Tsujimoto et al, 2004;2007b) for ~80-nm-sized PLGA nanospheres that can undergo sterile pressure filtration (Tsukada et al, 2009), for use in injectable pharmaceutical formulations. The study developed a production method for the practical use of PLGA nanospheres.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

Tanaka

Ochi

Sasai

et al. 2022

KONA

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Microspheres composed of poly (lactic-co-glycolic acid) (PLGA) were formed in liquid droplets using the electrospray technique. The structure of the microspheres was controlled by changing the electric voltage of the electrospray. PLGA microspheres with porous structures and micro-sized nanocomposite particles comprising PLGA nanosphere aggregates were formed at 5.0-7.0 kV and 2.5-3.5 kV, respectively. The structural change was related to the extent of evaporation of the solvent from the droplets during their flight. When the evaporation was completed in the relatively small droplets, the microspheres with porous structures were formed in the droplets. To study the mechanism, we observed the effects of the electric voltage of the electrospray, PLGA concentration, flight distance of the droplets, and molecular weight of PLGA on the structure of the PLGA particles. The novelty of this study is the analysis of the size and structure of the PLGA microparticles, which were controlled by the electrospray technique. Therefore, this research has important implications for the structural design and preparation of nanocomposite particles.

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Development of a PLGA-Nanosphere DDS Prepared by Spherical Crystallization with a Polymer

Kawashima

2019

Spherical Crystallization as a New Platform for Particle Design Engineering

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New Particle Design and Its Preparation of NFkB Decoy Oligodeoxynucleotide (NDON) Loaded PLGA Nanospheres for Gene Delivery

Cited by 9 publications

References 9 publications

Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

Development of a PLGA-Nanosphere DDS Prepared by Spherical Crystallization with a Polymer

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