New oxacycles on the block: benzodioxepinones via a Passerini reaction

Zingiridis, Marios; Loukopoulos, Edward; Neochoritis, Constantinos G.

doi:10.1007/s11030-022-10502-9

Mol Divers

2022

DOI: 10.1007/s11030-022-10502-9

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New oxacycles on the block: benzodioxepinones via a Passerini reaction

Marios Zingiridis

Edward Loukopoulos

Constantinos G. Neochoritis

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2024

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Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe

Fragkiadakis,

Fotopoulou,

Froudas

et al. 2024

Eur J Org Chem

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Cyclic N‐sulfonyl ketimines constitute an accessible class of lead‐like heterocycles with a vast application in both synthetic organic and medicinal chemistry. In this context, we harness the capabilities of these heterocycles in four different isocyanide‐based multicomponent reactions. Our goal was to create libraries of compounds with functional groups and vectors that are compatible for structural elaboration and optimization of their physical properties. We synthesized 15 unprecedented compounds with high diversity and complexity, whereas we have obtained four single crystal structures of each scaffold, unraveling their geometrical features and potential employment in drug discovery.

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Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe

Fragkiadakis,

Fotopoulou,

Froudas

et al. 2024

Eur J Org Chem

View full text Add to dashboard Cite

show abstract

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New oxacycles on the block: benzodioxepinones via a Passerini reaction

Cited by 1 publication

References 35 publications

Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe

Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe

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