New opportunities in the preparation of nanocomposites for biomedical applications: revised mechanosynthesis of magnetite–silica nanocomposites

Scano, Alessandra; Cabras, Valentina; Marongiu, Francesca; Peddis, Davide; Pilloni, Martina; Ennas, Guido

doi:10.1088/2053-1591/aa5867

Cited by 8 publications

(16 citation statements)

References 47 publications

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“…Spinel ferrite magnetic nanoparticles (MNPs) are attracting increasing interest due to the numerous areas of application that they have potential uses in, including biomedicine [1][2][3], magnetic resonance imaging (MRI) contrasting agents [4], drug delivery [5,6], and wastewater treatment [7]. A characteristic property exploited in all these applications is their superparamagnetism (SPM) [8].…”

Section: Introductionmentioning

confidence: 99%

Spinel Iron Oxide by the Co-Precipitation Method: Effect of the Reaction Atmosphere

et al. 2021

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Synthesis atmosphere (i.e., air and nitrogen) effects on the physical properties and formation mechanism of spinel iron oxide nanoparticles prepared via the co-precipitation method have been investigated using a multi-technique approach. The obtained magnetic nanoparticles (MNPs) were characterized using the X-ray diffraction, transmission electron microscopy (TEM), SQUID magnetometry, Mössbauer spectroscopy and X-ray absorption near-edge Structure spectroscopy techniques. The synthesis procedure leads to the formation of a spinel structure with an average crystallite size of 9.0(9) nm. The morphology of the particles synthetized under an inert atmosphere was quasi-spherical, while the nanoparticles prepared in air present a faceted shape. The small differences observed in morphological properties are explained by the influence of the reaction atmosphere on the formation mechanism of the MNPs. The magnetic characterization indicates that both samples exhibit superparamagnetic behavior at 300 K. The investigation by means of the Langevin approach at 300 K also leads to equal values for the mean size of the magnetic cores (Dm). Additionally, the analysis of the Mössbauer spectra revealed the lack of spin disorder for both samples, resulting in a high saturation magnetization. The fit of XANES spectrum suggests that about 2/3 of the iron ions reside in a local environment close to that of γ-Fe2O3 and about 1/3 close to that of Fe3O4 for the sample synthetized in inert atmosphere.

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Section: Introductionmentioning

confidence: 99%

Spinel Iron Oxide by the Co-Precipitation Method: Effect of the Reaction Atmosphere

et al. 2021

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“…In the pattern of samples prepared with the same amount of extract but different milling time, an enlargement of the SiO 2 haloes can be observed (e.g. S1 and S4 samples, Figure 1), due to the increase of the system disorder related to an increment of the milling time 18,19,24 …”

Section: Resultsmentioning

confidence: 99%

“…21,22 Our synthetic approach is completely new up-scaling of effective products. 24,37 In fact, while technologies are in principle available for large-scale fabrication, production of biomaterials is still expensive because of high-cost raw materials and equipment needed for their manufacturing. In addition, the production processes are usually complicated involving many steps.…”

Section: Discussionmentioning

confidence: 99%

“…29 3 | RESULTS AND DISCUSSION Figure 1), due to the increase of the system disorder related to an increment of the milling time. 18,19,24 SEM analysis revealed the presence of particle agglomeration, typical of the milled samples (Figure 2A-C). With an increment of the milling time, a decrease in the particle size and agglomeration are observed, simultaneously with the increase in the system disorder also observed in the XRPD patterns.…”

Section: Evaluation Of the Nanocomposite Protective Effect Against Ce...mentioning

confidence: 96%

“…Indeed, our previous studies already showed the controlled drug release capabilities of the silica matrix 18 while several reports suggest that silica can affect tissue repair by promoting cytokine generation for collagen synthesis (scarring), and the generation of new blood vessels (angiogenesis) 21,22 . Moreover, our new strategy benefits of the high availability of silica in nature, cost‐effective and easy to scale‐up production of the nanocomposites 23,24 . Along with the advantages described before, the incorporation of natural products in the silica‐based delivery system can protect the natural extract from physical and chemical degradation, therefore enhancing its bioavailability and pharmacological activity 17,18 …”

Section: Introductionmentioning

confidence: 91%

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Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Ebau

Scano

Manca

et al. 2022

J Biomedical Materials Res

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An innovative nanotechnology‐based approach was used for the preparation of Centella asiatica (C. asiatica) extract‐SiO2 nanocomposites, specifically tailored for skin protection from oxidative damage. Different amounts of C. asiatica glycolic extract (1.0, 3.0, 5.0, and 10.0 wt %) and fumed silica were used to prepare the nanocomposites by means of ball milling method. The influence of both composition of the starting mixture and milling time on the final products was evaluated by different techniques such as X‐ray powder diffraction, scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis, and nitrogen sorption analysis. Results confirmed the integrity of the natural extract after the milling process, and its successful loading in the silica matrix. No cytotoxicity was observed for the obtained nanocomposites, which showed high in‐vitro ability to scavenge 2,2‐diphenyl‐1‐picrylhydrazyl and to protect human keratinocytes from damages induced with hydrogen peroxide.

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Probing influence of rare earth ions (Er3+, Dy3+ and Gd3+) on structural, magnetic and optical properties of magnetite nanoparticles

Jain

Luthra²,

Gokhale

2018

Journal of Magnetism and Magnetic Materials

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New opportunities in the preparation of nanocomposites for biomedical applications: revised mechanosynthesis of magnetite–silica nanocomposites

Cited by 8 publications

References 47 publications

Spinel Iron Oxide by the Co-Precipitation Method: Effect of the Reaction Atmosphere

Spinel Iron Oxide by the Co-Precipitation Method: Effect of the Reaction Atmosphere

Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Probing influence of rare earth ions (Er3+, Dy3+ and Gd3+) on structural, magnetic and optical properties of magnetite nanoparticles

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New opportunities in the preparation of nanocomposites for biomedical applications: revised mechanosynthesis of magnetite–silica nanocomposites

Cited by 8 publications

References 47 publications

Spinel Iron Oxide by the Co-Precipitation Method: Effect of the Reaction Atmosphere

Spinel Iron Oxide by the Co-Precipitation Method: Effect of the Reaction Atmosphere

Centella asiaticaextract‐SiO2 nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Probing influence of rare earth ions (Er3+, Dy3+ and Gd3+) on structural, magnetic and optical properties of magnetite nanoparticles

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Product

Resources

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Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage