New Onset Autoimmune Diseases after the Sputnik Vaccine

Abstract

The vertiginous advance for identifying the genomic sequence of SARS-CoV-2 allowed the development of a vaccine including mRNA-based vaccines, inactivated viruses, protein subunits, and adenoviral vaccines such as Sputnik. This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. Patients and Methods: A retrospective study was conducted on patients with new-onset autoimmune diseases induced by a post-COVID-19 vaccine between March 2021 and December 2022, in two referral hospitals in Mexico City and Argentina. The study evaluated patients who received the Sputnik vaccine and developed recent-onset autoimmune diseases. Results: Twenty-eight patients developed recent-onset autoimmune diseases after Sputnik vaccine. The median age was 56.9 ± 21.7 years, with 14 females and 14 males. The autoimmune diseases observed were neurological in 13 patients (46%), hematological autoimmune manifestations occurred in 12 patients (42%), with thrombotic disease observed in 10 patients (28%), and autoimmune hemolytic anemia in two patients (7.1%). Rheumatological disorders were present in two patients (7.1%), and endocrine disorders in one patient (3.5%). Principio del formulario Conclusion: Although the COVID-19 Sputnik vaccine is generally safe, it can lead to adverse effects. Thrombosis and Guillain-Barre were the most frequent manifestations observed in our group of patients.

COVID‐19 vaccination and autoimmunity: Do we need more evidence?

“…2 Similarly, the vectored vaccine Sputnik has also been linked to the emergence of 28 cases of autoimmune conditions in Mexico and Argentina. 9 Alqatri et al reported that autoimmune cases were mostly linked to mRNA vaccines (Pfizer and Moderna), occurring within days to weeks after the administration of the first, second, or third doses, and were diagnosed using standard laboratory tests. 2 diabetes mellitus, and vasculitis.…”

“…However, there is a substantial body of evidence suggesting that both SARS-CoV-2 natural infection and COVID-19 vaccination (mRNA vaccines, vectored vaccines, and inactivated virus vaccines) are associated with the new onset or exacerbation of existing autoimmune and autoinflammatory conditions. [1][2][3][4][5][6][7][8][9] The question arises whether the current evidence is sufficient to confirm with postvaccination emergence of 31 cases of autoimmune conditions, including systemic lupus erythematosus (SLE), thyroiditis, Graves' disease, IgA vasculitis, inflammatory arthritis, dermatomyositis, ulcerative colitis, autoimmune hepatitis, autoimmune hemolytic anemia, autoimmune pancreatitis, ANCA vasculitis, myasthenia gravis, and Sjögren's syndrome (SS). 2 Similarly, the vectored vaccine Sputnik has also been linked to the emergence of 28 cases of autoimmune conditions in Mexico and Argentina.…”

COVID-19 and Autoimmunity: Do We Need More Evidence?

“…While it is an interesting observation, the measures of outcomes are limited by its sample size (n=12 versus n=8) and without any presented hazard ratios. However, there is a substantial body of evidence suggesting that both SARS-CoV-2 natural infection and COVID19 vaccination (mRNA vaccines, vectored-vaccines, and inactivated virus vaccines) are associated with the new onset or exacerbation of existing autoimmune and autoinflammatory conditions [1][2][3][4][5][6][7][8][9] . I would like to discuss if current evidence is enough to confirm COVID-19 and vaccination as risk factors for autoimmunity or if more evidence is needed.…”

“…Imperatively administration of mRNA vaccines (Pfizer and Moderna) and vectored vaccines (AstraZeneca) has been linked with post-vaccination emergence of 31 cases of autoimmune conditions, including systemic lupus erythematosus (SLE), thyroiditis, Graves' disease, IgA vasculitis, inflammatory arthritis, dermatomyositis, ulcerative colitis, autoimmune hepatitis, autoimmune hemolytic anemia, autoimmune pancreatitis, ANCA vasculitis, myasthenia gravis, and Sjögren's syndrome (SS). Next, the vectored vaccine Sputnik has also been linked to the emergence of 28 cases of autoimmune conditions in Mexico and Argentina 9 .…”