New oleanene-type triterpene saponins from <i>Pueraria peduncularis</i>

Li, Na; Min, Zhi-Da; Wu, Hou‐Ming

doi:10.1080/10286020290023988

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…In addition, the 13 C NMR spectrum exhibited one carbonyl at δ 216.7 and anomeric carbons at δ 105.2 and 103.5. The 1 H NMR and 13 C NMR data for compound 1 are presented in Table and are similar to the results of previous reports . On the basis of the aforementioned evidence, the molecular formula of compound 1 was confirmed as C 42 H 66 O 14 , and the structure (Fig.…”

Section: Resultssupporting

confidence: 87%

“…Here, we found two pentacyclic triterpenoid saponins, named pedunsaponin A and pedunsaponin C, in the roots of P. peduncularis , as previously described by Li et al , but their potential application as molluscicides was unknown until now. Both saponins showed high activity against P. canaliculata , and these results lay an important foundation for exploring the potential value of P. peduncularis as a molluscicide.…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Active saponins from root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their molluscicidal effects on Pomacea canaliculata

Yang

Zhang

Lei

et al. 2016

Pest Management Science

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Section: Resultssupporting

confidence: 87%

Section: Discussionsupporting

confidence: 78%

Active saponins from root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their molluscicidal effects on Pomacea canaliculata

Yang

Zhang

Lei

et al. 2016

Pest Management Science

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“…To better develop and utilize the resources of P. peduncularis , researchers have studied the chemical composition of P. peduncularis . flavonoids, saponins, esters, amino acids and other substances have been identified from P. peduncularis . However, there are still many components that have not yet been identified, and the relationship between the biological activities and different compounds is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…flavonoids, saponins, esters, amino acids and other substances have been identified from P. peduncularis. 21 However, there are still many components that have not yet been identified, and the relationship between the biological activities and different compounds is not clear. In this paper, eight compounds were isolated and identified from P. peduncularis.…”

Section: Discussionmentioning

confidence: 99%

Compounds from the root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their antimicrobial effects

Chen

Zhao

et al. 2019

Pest Management Science

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BACKGROUND Pueraria peduncularis belongs to the genus Pueraria DC, and has a wide range of medical and agricultural activities. Previous studies have shown that P. peduncularis extracts have broad bioactivities against phytopathogens. In this paper, we systematically studied the fungicidal activity of root methanol extracts and further isolated the active compounds. RESULTS The root methanol extract inhibited the mycelial growth of the five tested phytopathogens to different degrees. Among these phytopathogens, the inhibitory effect was greatest against R. solani, with an EC50 value of 324.72 mg L−1. Eight compounds were subsequently isolated and identified from P. peduncularis. Among them, puercarpan A and medicarpin showed strong fungicidal activity, with MIC values against Rhizoctonia solani of 1.6 and 6.25 mg L−1, respectively. Puercarpan A is a new compound, and its structure was established as (6aR,6bS,11aR)‐6b‐hydroxy‐3‐methoxypterocarpan‐10‐ene‐7‐one. CONCLUSION The P. peduncularis extracts exhibit high antimicrobial activity against R. solani and have great potential value of P. peduncularis as a fungicide. © 2019 Society of Chemical Industry

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“…The 1 H-NMR and 13 C-NMR data are similar to the results of previously conducted studies. 20 On the basis of the aforementioned facts, compound 7 (Figure 1) was thus determined as pedunsaponin A, with a molecular formula of C 42 H 66 O 15 .…”

Section: Resultsmentioning

confidence: 99%

Compounds From the Root of Pueraria peduncularis (Grah. ex Benth.) Benth. and Their Antitumor Effects

Chen

Qian²,

Zhao

et al. 2019

Natural Product Communications

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Pueraria peduncularis belongs to the genus Pueraria DC., and has a wide range of medicinal and agricultural values. Previous studies have shown that methanol extracts of P. peduncularis had broad range bioactivities against different pests such as insects, phytopathogens, and snails; however, the specific studies with regard to active compounds against these pests have not been reported. In the current study, we systematically assessed the effects of P. peduncularis root extract against cancer cells, and we also isolated, purified, and analyzed the active ingredients of 8 different compounds from the root of P. peduncularis. To the best of our knowledge, coumestrol (compound 1), lupinalbin A (compound 2), wighteone (compound 6), and erythrinin C (compound 4) were the first isolated from the P. peduncularis root in our study. The extract of the P. peduncularis root had a significantly strong cytotoxic activity on the lung adenocarcinoma cell line A549 (31.0%) and breast cancer cell line MCF-7 (33.0%), respectively. Lupinalbin A (compound 2), erythrinin C (compound 4), pedunsaponin A (compound 7), and pedunsaponin C (compound 8) had more than 40% inhibitory effects on the lung adenocarcinoma line A549. Whereas erythrinin C (compound 4) and pedunsaponin C inhibited more than 47% breast cancer cell lines MCF-7. These results indicate that P. peduncularis is rich in anticancer substances that laid the foundation for a further understanding of P. peduncularis and need to be further explored for other diseases.

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New oleanene-type triterpene saponins from Pueraria peduncularis

Cited by 7 publications

References 5 publications

Active saponins from root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their molluscicidal effects on Pomacea canaliculata

Active saponins from root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their molluscicidal effects on Pomacea canaliculata

Compounds from the root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their antimicrobial effects

Compounds From the Root of Pueraria peduncularis (Grah. ex Benth.) Benth. and Their Antitumor Effects

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