Eur. J. Chem. volume 8, issue 2, P119-124 2017 DOI: 10.5155/eurjchem.8.2.119-124.1549
Hossameldin Ali Aziz, Gamal Abdeltawab Idris Moustafa, Samar Hafez Abbas, Sayed Mohamed Derayea, Gamal El-Din Ali Ahmed Abuo-Rahma

Oximes and nitrate esters are considered as important nitric oxide (NO) donors with diverse biological activities. Herein, we report the synthesis and characterization of new oxime and nitrate ester derivatives of norfloxacin as potential NO donor hybrids with expected synergistic antimicrobial activity. The release of NO from those hybrids was measured by a modified Griess method in which p-nitroaniline was employed instead of sulfanilamide. The increased electrophilicity of the intermediate 4-nitroanili…


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