2012
DOI: 10.18632/aging.100496
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The nutrient-sensing mTOR (mammalian Target of Rapamycin) pathway regulates cellular metabolism, growth functions, and proliferation and is involved in age-related diseases including cancer, type 2 diabetes, neurodegeneration and cardiovascular disease. The inhibition of mTOR by rapamycin, or calorie restriction, has been shown to extend lifespan and delays tumorigenesis in several experimental models suggesting that rapamycin may be used for cancer prevention. This requires continuous long-term treatment maki… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
68
0

Year Published

2012
2012
2014
2014

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 93 publications
(70 citation statements)
references
References 30 publications
(70 reference statements)
2
68
0
Order By: Relevance
“…87 Similarly, rapamycin delayed cancer in p53 +/− and p53 −/− mice. 63,64 Noteworthy, the effect of rapamycin was blunted when it was used later in life, consistent with its indirect anti-cancer effect. 63 In conclusion, mice lacking p53 is characterized by oncophilic metabolism, an additional factor fostering carcinogenesis.…”
Section: Discussionmentioning
confidence: 85%
See 1 more Smart Citation
“…87 Similarly, rapamycin delayed cancer in p53 +/− and p53 −/− mice. 63,64 Noteworthy, the effect of rapamycin was blunted when it was used later in life, consistent with its indirect anti-cancer effect. 63 In conclusion, mice lacking p53 is characterized by oncophilic metabolism, an additional factor fostering carcinogenesis.…”
Section: Discussionmentioning
confidence: 85%
“…[60][61][62] Rapamycin extends lifespan and delays cancer in p53 +/− and p53 −/− mice. [63][64][65] In p53 −/− mice both direct (anti-cancer) and indirect (anti-aging) models identically predict that rapamycin will delay cancer and extend life span. There is a hint for indirect effects: rapamycin is more effective when given early in life.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the current data show that increased longevity is associated with little change in end-of-life pathology. Because cancer is the primary cause of death in UM-HET3 and C57BL (14)(15)(16)(17).…”
Section: A Comprehensive Assessment Of Aging In Micementioning
confidence: 99%
“…66 Therefore, it is noteworthy that rapamycin also ameliorates a lamin A defect, deleted for p53 and expressing mutant K-Ras, 44 and rapamycin delayed the onset or progression of tumors in p53 -/-and p53 +/-mice to extend their lifespan. 45,46 Thus, rapamycin's dependence on p53 for suppressing tumor growth could be influenced by context and might not be absolute.…”
Section: Conclusion: Orpheus Takes a Look Backmentioning
confidence: 99%