“…The absolute FA values are sensitive to fiber coherence, myelination levels, and axonal integrity, and have been widely used as an index of white matter integrity (Thomason and Thompson, 2011). FA has emerged as a sensitive index of diffuse abnormalities in many brain disorders including Alzheimer’s disease (AD) (Clerx et al, 2012; Teipel et al, 2012); in many studies, it is related to cognitive performance (Penke et al, 2010a; Penke et al, 2010b) and is altered in numerous psychiatric disorders including major depressive disorder (Carballedo et al, 2012) and bipolar disorder (Barysheva et al, 2012; Sprooten et al, 2011). Patient-control differences in FA values are also among the most replicable and consistent neuroimaging findings in schizophrenia (Alba-Ferrara and de Erausquin, 2013; Friedman et al, 2008; Kochunov et al, 2012a; Mandl et al, 2012; Nazeri et al, 2012; Perez-Iglesias et al, 2011).…”