2012
DOI: 10.3233/jad-2011-110797
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Abstract: The aim of the present study is to evaluate the diagnostic value of diffusion tensor imaging (DTI) for early Alzheimer's disease (AD) in comparison to widely accepted medial temporal lobe (MTL) atrophy measurements. A systematic literature research was performed into DTI and MTL atrophy in AD and mild cognitive impairment (MCI). We included seventy-six studies on MTL atrophy including 8,122 subjects and fifty-five DTI studies including 2,791 subjects. Outcome measure was the effect size (ES) expressed as Hedge… Show more

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Cited by 116 publications
(82 citation statements)
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References 170 publications
(27 reference statements)
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“…This is in line with many prior studies. A recent AD DTI review found that MD values have more discriminative power than FA values and higher effect sizes for detecting disease related effects - derived from 55 different studies - in the frontal, parietal, occipital and temporal lobes (Clerx et al, 2012; Nir et al, 2013). We also found significant associations between FA and MD MDP measures and cognitive deficits, as measured by MMSE scores, across all subjects.…”
Section: Discussionmentioning
confidence: 99%
“…This is in line with many prior studies. A recent AD DTI review found that MD values have more discriminative power than FA values and higher effect sizes for detecting disease related effects - derived from 55 different studies - in the frontal, parietal, occipital and temporal lobes (Clerx et al, 2012; Nir et al, 2013). We also found significant associations between FA and MD MDP measures and cognitive deficits, as measured by MMSE scores, across all subjects.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies with DWI reveal widespread disease effects on the brain's white matter (Clerx et al, 2012, Nir et al, 2013, Jahanshad et al, 2012). The spread of white matter degeneration may be due in part to Wallerian or ‘backward’ neurodegeneration, in which gray matter atrophy leads to axonal degeneration (Coleman, 2005; Ewers et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…DWI is increasingly used (Mori and van Zijl, 2002; Basser and Jones, 2002) to study fiber integrity and microstructure, based on indices such as the mean diffusivity and fractional anisotropy of local water diffusion (Clerx et al, 2012). Furthermore, diffusion-based tractography can infer patterns of structural connectivity and is one of the primary quantitative methods to study the 3D course of long fibers ( i.e.…”
Section: Introductionmentioning
confidence: 99%
“…The absolute FA values are sensitive to fiber coherence, myelination levels, and axonal integrity, and have been widely used as an index of white matter integrity (Thomason and Thompson, 2011). FA has emerged as a sensitive index of diffuse abnormalities in many brain disorders including Alzheimer’s disease (AD) (Clerx et al, 2012; Teipel et al, 2012); in many studies, it is related to cognitive performance (Penke et al, 2010a; Penke et al, 2010b) and is altered in numerous psychiatric disorders including major depressive disorder (Carballedo et al, 2012) and bipolar disorder (Barysheva et al, 2012; Sprooten et al, 2011). Patient-control differences in FA values are also among the most replicable and consistent neuroimaging findings in schizophrenia (Alba-Ferrara and de Erausquin, 2013; Friedman et al, 2008; Kochunov et al, 2012a; Mandl et al, 2012; Nazeri et al, 2012; Perez-Iglesias et al, 2011).…”
Section: Introductionmentioning
confidence: 99%