Biochemical Pharmacology volume 80, issue 1, P13-21 2010 DOI: 10.1016/j.bcp.2010.02.017 View full text
Maria José Alcaraz, Javier Megías, Isabel García-Arnandis, Victoria Clérigues, Maria Isabel Guillén

Abstract: Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Current treatments are focused on symptomatic relief but they lack efficacy to control the progression of this disease which is a leading cause of disability. Therefore, the development of effective disease-modifying drugs is urgently needed. Different initiatives are in progress to define the molecular mechanisms involved in the initiation and progre…

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