New model for the secondary structure of the 5′ non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence

Skinner, Michael A.; Racaniello, Vincent R.; Dunn, Glynis; Cooper, J. I.; Pd, Minor; Almond, J. W.

doi:10.1016/0022-2836(89)90261-1

Cited by 284 publications

(210 citation statements)

References 30 publications

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“…It has been demonstrated with poliovirus that 5'-terminal 90 nucleotides forms a cloverleaf-like secondary structure which is essential for replication (Skinner et al, 1989;Toyoda et al ., 1993). However, such unique structure has not been observed in the isolates (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Molecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis

Jung

Kim²,

Paik³

1998

Exp Mol Med

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In Korea, there was a big outbreak of aseptic meningitis in 1993. Six clinical isolates of enterovirus were obtained from patients with aseptic meningitis and were identified as echovirus type 9 by serotyping with a pool of neutralizing antisera. For molecular characterization of the isolates, the nucleotide sequences of 5'-noncoding region (NCR), VP4, VP2, VP1, 2A and 2C regions of the isolates were compared with the corresponding regions of echovirus type 9 Hill and Barty strains. Unlike Hill strain, Barty strain contained a C-terminal extension to the capsid protein V P 1 with an RGD (argnine-glycine-aspartic acid) motif. To determine whether similar structural features were present in our isolates, their nucleotide sequences including the VP1 region were analyzed. All isolates exhibited the VP1 extension with the RGD motif. We concluded the Korean isolates in the year of 1993 as the echovirus type 9 Barty strain although the isolates showed 15-20% nucleotide sequence differences in the several genomic regions.

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Section: Discussionmentioning

confidence: 99%

Molecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis

Jung

Kim²,

Paik³

1998

Exp Mol Med

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“…A similar model seems to be applicable to the cardioviruses and to TMEV and this, together with the biochemical data, suggests that these structures do exist in vivo and have functional significance. In the case of enteroo and rhinoviruses, computer predictions, again augmented by experimental analysis, have produced a compelling model applicable to all the viruses studied but different from the predicted folding of the cardio-and aphthoviruses (Rivera et al, 1988;Pilipenko et al, 1989b;Skinner et al, 1989). There are three main predicted structural domains located at positions 236 to 443, 451 to 559 and 581 to 620 (numbers refer to poliovirus type 3) and all are supported by observed covariance.…”

Section: G Stanwaymentioning

confidence: 99%

Structure, function and evolution of picornaviruses

Stanway

1990

Journal of General Virology

161

105

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“…Finally, neuroinvasiveness has been mapped to unexpected regions of viral genomes, including non-coding sequences in poliovirus (Macadam et al, 1994) and Sindbis virus (Dubuisson et al, 1997). It has been suggested that sequences in these regions are critical for formation of stem-loop structures, which are required for ef®cient translation of viral genes (Skinner et al, 1989;Strauss and Strauss, 1994).…”

Section: Molecular and Genetic Determinants Of Microbial Neuroinvasionmentioning

confidence: 99%

Molecular and cellular mechanisms for microbial entry into the CNS

Zhang¹,

Tuomanen²

1999

J Neurovirol

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A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites are capable of entry into the central nervous system (CNS) and cause a variety of clinical manifestations. The cellular and molecular mechanisms for the CNS invasion have been extensively studied in the last two decades. Viruses invade neurons and thereby cause encephalitis or peripheral neuritis, while bacteria enter the cerebrospinal¯uid (CSF) and cause meningitis. In contrast, the mechanisms for parasitic neuroinvasion are much more complex and less clear. The capabilities that enable these elite subsets of pathogens to engineer uptake into the CNS will be the subject of this review.

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New model for the secondary structure of the 5′ non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence

Cited by 284 publications

References 30 publications

Molecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis

Molecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis

Structure, function and evolution of picornaviruses

Molecular and cellular mechanisms for microbial entry into the CNS

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