New metal complexes derived from diacetylmonoxime-n(4)antipyrinylthiosemicarbazone: Synthesis, characterization and evaluation of antitumor activity against Ehrlich solid tumors induced in mice

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

“…(ii) a negative shift of the stretching frequency bands of hydrazonic and oximatic azomethine groups by 19–41 and 8–50 cm −1 correspondingly. (iii) a positive shift of the stretching frequency band of oximatic linkage (N–O) by 106–158 cm −1 referring to the participation of oximatic moiety in chelation via the nitrogen atom rather than the oxygen atom 58 . Second, hydrazone–oxime (H 2 L,1) can also interact as a mono‐negative tridentate chelator with Cu 2+ ( 3 – 4 ), Co 2+ , Ni 2+ , and UO 2 2+ ions in which is attached covalency via the enolic carbonylic oxygen (O18) and chelated through the nitrogen atom of the hydrazonoic and oximatic azomethine groups (N14&N3).…”

“…(ii) a negative shift of the stretching frequency bands of hydrazonic and oximatic azomethine groups by 14–33 and 5–30 cm −1 correspondingly. (iii) the appearance of the stretching frequency bands of oximatic hydroxyl group around the same position and the positive shifting of the stretching frequency band of oximatic linkage (N–OH) by 81–115 cm −1 referring to the participation of oximatic moiety in chelation in its protonated form via the nitrogen atom instead of the oxygen atom 58 . Third, hydrazone–oxime (H 2 L,1) linked the Cu 2+ cation as in complex ( 5 ) as a neutral tridentate in which it chelated through the ketonic carbonyl oxygen atom of the hydrazonic(O18) as well as hydrazonoic and oximatic azomethine groups (N3&N14) 58 .…”

“…(i) The presence of stretching frequency bands of hydrazonic NH and oximatic hydroxyl groups in the same position implies that the hydrazone oxime ( H 2 L,1 ) interacts in its protonated form (ii) a negative shift of the stretching frequency bands of ketonic carbonyl, hydrazonic and oximatic azomethine groups by 14, 20, and 17 cm −1 correspondingly. (iii) a positive shift of the stretching frequency band of oximatic linkage (N–OH) by 70 cm −1 referring to the participation of oximatic moiety in chelation via the nitrogen atom instead of the oxygen atom 58 . The chelation of metallic cations was endorsed by the appearing of new stretching frequency bands in the 602–514, 478–526, and 419–460 cm −1 ranges ascribing to the ν(M–O) ν(N–M) and ν(M ← N) correspondingly 59 .…”

“…58 The chelation of metallic cations was endorsed by the appearing of new stretching frequency bands in the 602-514, 478-526, and 419-460 cm À1 ranges ascribing to the ν(M-O) ν(N-M) and ν(M N) correspondingly. 59 The FT-IR spectra of acetate complexes (4), (6), and (7) displayed stretching frequency bands in the 1566-1571 and 1361-1370 cm À1 range which implying to ν as (COO À ) and ν s (COO À ) of the acetate anions. The differences between the two stretching frequency bands (Δ = ν as À ν s ) were 200, 209, and 199 cm À1 suggesting that the acetate anions attached to the Cu 2+ , Co 2+ , and Ni 2+ cations as a unidentate fashion.…”

New phthalimide analog ameliorates CCl4 induced hepatic injury in mice via reducing ROS formation, inflammation, and apoptosis

“…Polyclonal rabbit anti-VEGF antibody at 1:100 dilution (Thermo Fisher Scientific, Waltham, MA, USA), poly clonal antibody of TNF-α (Invitrogen, USA), NF-κB-p65 at dilution 1:100 (Rel A, ab-1 rabbit polyclonal, Thermo Fisher Scientific, Waltham, MA, USA) and anti-PCNA (clone PC10; 1:200 Dako, Glostrup, Denmark) were involved in the assay. The percentage of positive cells per total 1000 counted cells in eight high power fields was used to represent the labeling index as previously reported ( El-Aarag et al, 2021 , El-Saied et al, 2019 ).…”