New markers of urinary tract infection

Masajtis-Zagajewska, Anna; Nowicki, Michał

doi:10.1016/j.cca.2017.06.003

Cited by 65 publications

(42 citation statements)

References 64 publications

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“…Therefore, other markers for diagnosing UTI are needed. And several studies for new markers such as procalcitonin and leukocyte esterase have been conducted recently 4,7) .…”

Section: Introductionmentioning

confidence: 99%

Association of Neutrophil Gelatinase associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infections

2020

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To investigate the association between urinary neutrophil gelatinaseassociated lipocalin (uNGAL) and leukocyte differential count in children with urinary tract infections (UTIs). Methods: A retrospective chart review was performed in children undergoing uNGAL measurements between June 2018 and September 2019. Patients with suspected or diagnosed UTIs were included. The relationship between uNGAL and blood leukocyte differential count was investigated in children. Results: A total of 197 children were included in this study, 119 of whom (60%) had UTIs. The non-UTI patients (n=78) were diagnosed with pneumonia, acute gastroenteritis, viral upper respiratory infection, and others. After adjusting for age, gender, and fever duration, the leukocyte count, monocyte count, and uNGAL levels were higher in the UTI group than in the non-UTI group (P<0.05). uNGAL showed positive correlations with neutrophil counts, monocyte counts, the neutrophil-to-lymphocyte ratio, and the monocyte-to-lymphocyte ratio in the UTI group (P<0.05). uNGAL levels were only associated with the neutrophil-tolymphocyte ratio in the non-UTI group (P<0.05). In a multivariable logistic regression analysis, only uNGAL was associated with the presence of UTI (P<0.05). The area under the receiver operating characteristic curves for uNGAL and monocyte counts to identify UTI were 0.89 (95% confidence interval (CI): 0.824-0.939; P= 0.025) and 0.7 (95% CI: 0.627-0.774; P=0.038), respectively. Conclusions: In children with UTIs, uNGAL levels may be associated with blood leukocyte differential counts. uNGAL measurements and monocyte counts can be helpful in children with suspected UTIs.

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“…Therefore, other markers for diagnosing UTI are needed. And several studies for new markers such as procalcitonin and leukocyte esterase have been conducted recently 4,7) .…”

Section: Introductionmentioning

confidence: 99%

Association of Neutrophil Gelatinase associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infections

2020

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“…Inflammation caused by infectious agents or environmental conditions has now been put forward as a possible cause for an increased prostate cancer (PCa) risk. Lower urinary tract infections are one example of such infections that are known to cause inflammation [ 1 ]. In addition, certain microorganisms have been implicated in the role of carcinogenesis [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A case-control study of lower urinary-tract infections, associated antibiotics and the risk of developing prostate cancer using PCBaSe 3.0

et al. 2018

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ObjectivesTo investigate the association between lower urinary-tract infections, their associated antibiotics and the subsequent risk of developing PCa.Subjects/Patients (or materials) and methodsUsing data from the Swedish PCBaSe 3.0, we performed a matched case-control study (8762 cases and 43806 controls). Conditional logistic regression analysis was used to assess the association between lower urinary-tract infections, related antibiotics and PCa, whilst adjusting for civil status, education, Charlson Comorbidity Index and time between lower urinary-tract infection and PCa diagnosis.ResultsIt was found that lower urinary-tract infections did not affect PCa risk, however, having a lower urinary-tract infection or a first antibiotic prescription 6–12 months before PCa were both associated with an increased risk of PCa (OR: 1.50, 95% CI: 1.23–1.82 and 1.96, 1.71–2.25, respectively), as compared to men without lower urinary-tract infections. Compared to men with no prescriptions for antibiotics, men who were prescribed ≥10 antibiotics, were 15% less likely to develop PCa (OR: 0.85, 95% CI: 0.78–0.91).ConclusionPCa was not found to be associated with diagnosis of a urinary-tract infection or frequency, but was positively associated with short time since diagnoses of lower urinary-tract infection or receiving prescriptions for antibiotics. These observations can likely be explained by detection bias, which highlights the importance of data on the diagnostic work-up when studying potential risk factors for PCa.

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“…The urine dipsticks test is commonly used for presumptive diagnosis of UTIs: it detects the presence of biochemical markers in urine samples which may be useful to establish the diagnosis of UTI [2]. Although many urine biomarkers for UTIs have recently been considered [45], markers that showed best results in diagnostic accuracy are nitrite and leukocyte esterase [6]. Although being cost-effective [46], such test shows low sensitivity that limits its clinical usefulness, [6] and analysis may be biased since a number of bacterial species are unreactive in these tests (e.g., no reduction of nitrates) [47,48].…”

Section: Alternative and Non-culture-based Methods For The Detection mentioning

confidence: 99%

Management of Urinary Tract Infections: Problems and Possible Solutions

Murgia¹,

Stalio²,

Arienzo³

et al. 2018

Urinary Tract Infection - The Result of the Strength of the Pathogen, or the Weakness of the Host

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In clinically suspected urinary tract infections (UTIs), empirical antibiotic treatment is usually started long before the laboratory results of urine culture and antibiogram are available. Although molecular diagnostic approaches are being applied to the diagnosis of many infections, UTIs are generally diagnosed by traditional culture methods. Patient care could greatly benefit from the development of a rapid, accurate, inexpensive test that could be done at patient's bedside, allowing the practitioner to plan targeted, more effective therapy. Such a test would potentially reduce incorrect or unnecessary use of antibacterial drugs and reduce the emergence of bacterial resistance. In response to this pressing and unmet clinical need, several methods have been developed in the last few years. Among these, the new point-of-care test (POCT) for detecting UTIs named Micro Biological Survey (MBS) UTI CHECK holds promise, as it allows semi-quantitative determination of bacterial load in urine leading to a fast detection of UTIs and to evaluation of bacterial antibiotic susceptibility. This new technology operates through a colorimetric survey performed in low-cost, ready-to-use, disposable vials, in which 1 ml of urine is inoculated without any preliminary treatment and requiring neither specialized personnel nor a specialized equipment.

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New markers of urinary tract infection

Cited by 65 publications

References 64 publications

Association of Neutrophil Gelatinase associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infections

Association of Neutrophil Gelatinase associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infections

A case-control study of lower urinary-tract infections, associated antibiotics and the risk of developing prostate cancer using PCBaSe 3.0

Management of Urinary Tract Infections: Problems and Possible Solutions

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