2015
DOI: 10.5935/0101-2800.20150077
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Abstract: Diabetes mellitus is a common chronic metabolic disease worldwide whose prevalence has increased during the last decades. Besides its more commonly recognized complications, such as macrovascular disease, retinopathy, nephropathy and neuropathy, diabetes related bone disease has gained growing attention. Diabetic patients are more prone to fracture than the general population as well as to low turnover bone disease in the chronic kidney disease setting. In this review, we discuss the relationship between diabe… Show more

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Cited by 12 publications
(12 citation statements)
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References 38 publications
(12 reference statements)
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“…Current studies support the involvement of metabolic changes associated with T2DM in bone deterioration in terms of metabolism, structure and resistance. Chronic hyperglycemia affects both the bone cell component and the extracellular matrix by accumulating the final products of advanced glycation (AGEs) [1,2,[10][11][12]. This is responsible for collagen bone matrix stiffening, that would allow the formation and propagation of micro-cracks throughout bone matrix [11].…”
Section: Introductionmentioning
confidence: 99%
“…Current studies support the involvement of metabolic changes associated with T2DM in bone deterioration in terms of metabolism, structure and resistance. Chronic hyperglycemia affects both the bone cell component and the extracellular matrix by accumulating the final products of advanced glycation (AGEs) [1,2,[10][11][12]. This is responsible for collagen bone matrix stiffening, that would allow the formation and propagation of micro-cracks throughout bone matrix [11].…”
Section: Introductionmentioning
confidence: 99%
“…Um método comumente empregado para avaliação da neuropatia diabética é o monofilamento (18 A literatura demonstra ainda que os pacientes neuropatas dependem enormemente de informações visuais como estratégia de controle postural (8). Porém, sabe-se que muitos diabéticos também apresentam retinopatias, podendo prejudicar ainda mais seu equilíbrio estático e dinâmico.…”
Section: Fundamentação Teóricaunclassified
“…Logo, entende-se que existe aumento no risco de fratura na diabetes, devido tanto a uma maior frequência de quedas quanto à menor resistência óssea. Uma recente revisão de literatura a respeito do metabolismo ósseo no diabetes explica essa fisiopatologia (18).…”
Section: Fundamentação Teóricaunclassified
“…Diabetes mellitus(DM), notably, type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease (1) . In the last two centuries; pathogenesis, epidemiology, prevention, and treatment of DM have been well established (2) .…”
Section: Introductionmentioning
confidence: 99%